公开(公告)号：US20090099363A1

公开(公告)日：2009-04-16

申请号：US12298409

申请日：2007-04-25

Applicant: Saxena Rahul ,  Verma Naresh Kumar ,  Srinivasan Chidambaram Venkateswaran ,  Wadhwa Lalit

Inventor： Saxena Rahul ,  Verma Naresh Kumar ,  Srinivasan Chidambaram Venkateswaran ,  Wadhwa Lalit

IPC: C07D495/04

CPC classification number: C07D495/04

Abstract: The present invention relates to a novel process for the preparation of polymorphic forms of clopidogrel hydrogen sulfate, namely methyl(+)-(S)-α-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate hydrogen sulfate of formula (I). Particularly the present invention relates to the process for the preparation of form (I) and amorphous clopidogrel hydrogen sulfate.

Abstract translation: 本发明涉及一种制备氯吡格雷硫酸氢盐多形态的新方法，即（+） - （S）-α-（邻氯苯基）-6,7-二氢噻吩并[3,2-c]吡啶 -5（4H） - 乙酸乙酯硫酸氢盐。 特别地，本发明涉及制备形式（I）和无定形氯吡格雷硫酸氢盐的方法。