公开(公告)号：US06486318B1

公开(公告)日：2002-11-26

申请号：US09983897

申请日：2001-10-26

Applicant: Verma Pradeep Kumar ,  Agarwal Ashutosh ,  Bhardwaj Nikhlesha Chandra ,  Singh Samir Kumar

Inventor： Verma Pradeep Kumar ,  Agarwal Ashutosh ,  Bhardwaj Nikhlesha Chandra ,  Singh Samir Kumar

IPC: C07F306

CPC classification number: C07D213/803 ,  A23L33/165 ,  A61K31/555 ,  C07D213/79

Abstract: The present invention relates to a single pot process for the preparation of metal picolinates useful as dietary supplement from alpha picoline, said process comprising hydrosulphonation of alpha picoline with sulphuric acid; heating the reaction mixture thus obtained between the range of 150° to 210° C. followed by oxidation with any suitable oxidizing agent to obtain alpha picolinic acid sulphate, and treating the thus obtained alpha picolinic acid sulphate with a metal salt solution to obtain corresponding metal picolinate.

Abstract translation: 本发明涉及一种用于制备可用作α-甲基吡啶膳食补充剂的金属吡啶甲酸盐的单盆法，所述方法包括用硫酸将α-甲基吡啶加氢磺化; 将由此获得的反应混合物加热到150-210℃，然后用任何合适的氧化剂氧化，得到α-吡啶甲酸硫酸盐，并用金属盐溶液处理由此得到的α-吡啶甲酸硫酸盐，得到相应的金属 皮奥兰特