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1.发明授权公开(公告)号：US09023390B2
公开(公告)日：2015-05-05
申请号：US13496818
申请日：2009-12-31
申请人： Christian F. Wertz , James S. Jensen , Victoria Ann O'Neill , Sean B. Mahoney , Stephen M. Berge
发明人： Christian F. Wertz , James S. Jensen , Victoria Ann O'Neill , Sean B. Mahoney , Stephen M. Berge
IPC分类号： A61K9/20 , A61K31/44 , A61K31/19 , A61K31/13 , A61K31/135 , A61K31/46 , A61K31/485
CPC分类号： A61K9/2054 , A61K9/2013 , A61K31/13 , A61K31/135 , A61K31/138 , A61K31/19 , A61K31/192 , A61K31/46 , A61K31/485 , A61K2300/00
摘要： Sustained-release oral pharmaceutical compositions and methods of use, wherein the compositions are in a single dosage form and include an amine-containing compound (including salts thereof), a salt of a non-steroidal anti-inflammatory drug (NSAID), and a hydrophilic matrix.
摘要翻译： 持续释放的口服药物组合物和使用方法，其中所述组合物为单一剂型，并且包括含胺化合物（包括其盐），非甾体抗炎药（NSAID）的盐和 亲水基质。
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2.发明申请SUSTAINED RELEASE COMPOSITION COMPRISING AN AMINE AS ACTIVE AGENT AND A SALT OF A CYCLIC ORGANIC ACID 审中-公开包含胺作为活性剂和循环有机酸的盐的持续释放组合物公开(公告)号：US20130237559A1
公开(公告)日：2013-09-12
申请号：US13807174
申请日：2011-06-29
IPC分类号： A61K31/485 , A61K31/192 , A61K31/135
CPC分类号： A61K9/2013 , A61K9/2054 , A61K31/135 , A61K31/137 , A61K31/192 , A61K31/485
摘要： The present invention provides sustained-release oral pharmaceutical compositions and methods of use. The sustained-release oral pharmaceutical compositions include an amine-containing compound (e.g., an opioid) (including salts thereof) and a pharmaceutically acceptable salt of a non-NSAID cyclic organic acid compound.
摘要翻译： 本发明提供持续释放的口服药物组合物和使用方法。 持续释放的口服药物组合物包括含有胺的化合物（例如阿片样物质）（包括其盐）和非NSAID环状有机酸化合物的药学上可接受的盐。
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公开(公告)号：US20110275658A1
公开(公告)日：2011-11-10
申请号：US13142784
申请日：2009-12-31
申请人： Kenneth L. Evenstad , Christian F. Wertz , James S. Jensen , Victoria Ann O'Neill , Stephen M. Berge
发明人： Kenneth L. Evenstad , Christian F. Wertz , James S. Jensen , Victoria Ann O'Neill , Stephen M. Berge
IPC分类号： A61K31/485 , A61P25/04 , A61K31/192
CPC分类号： A61K9/2054 , A61K9/2013 , A61K31/10 , A61K31/135 , A61K31/19 , A61K31/192 , A61K31/439 , A61K31/485 , A61K2300/00
摘要： The present invention provides sustained-release oral pharmaceutical compositions and methods of use. The sustained-release oral pharmaceutical compositions include an opioid (including salts thereof) and a salt of a non-steroidal anti-inflammatory drug (NSAID).
摘要翻译： 本发明提供持续释放的口服药物组合物和使用方法。 缓释口服药物组合物包括阿片样物质（包括其盐）和非甾体抗炎药（NSAID）的盐。
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公开(公告)号：US20100221328A1
公开(公告)日：2010-09-02
申请号：US12650149
申请日：2009-12-30
CPC分类号： A61K31/13 , A61K9/2081 , A61K9/4808 , A61K9/5047 , A61K9/5078
摘要： Described herein are extended-release or sustained-release formulations suitable for highly soluble pharmacologically active compounds, for example, amantadine. Dosage units for providing extended release are provided by the present invention. In some embodiments, the dosage unit comprises a plurality of coated beads having drug layer and a coating layer, wherein the coating layer comprises an ethylcellulose polymer. In some embodiments, near zero-order release of the active compound is achieved.
摘要翻译： 本文描述了适用于高度可溶性药理学活性化合物例如金刚烷胺的延长释放或持续释放制剂。 用于提供延长释放的剂量单位由本发明提供。 在一些实施方案中，剂量单位包括具有药物层和涂层的多个涂覆的珠，其中所述涂层包含乙基纤维素聚合物。 在一些实施方案中，实现了活性化合物的接近零级释放。
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5.发明申请Sustained-Released Product Comprising a Combination of a Non-Opioid Amine and a Non-Steroidal, Anti-Inflammatory Drug 有权持续释放的产品包含非阿片样胺和非类固醇，抗炎药物的组合公开(公告)号：US20150238423A1
公开(公告)日：2015-08-27
申请号：US14697891
申请日：2015-04-28
申请人： CHRISTIAN F. WERTZ , JAMES S. JENSEN , VICTORIA ANN O'NEILL , SEAN B. MAHONEY , STEPHEN M. BERGE
发明人： CHRISTIAN F. WERTZ , JAMES S. JENSEN , VICTORIA ANN O'NEILL , SEAN B. MAHONEY , STEPHEN M. BERGE
IPC分类号： A61K9/20 , A61K31/192 , A61K31/138 , A61K31/46 , A61K31/13 , A61K31/485 , A61K31/135
CPC分类号： A61K9/2054 , A61K9/2013 , A61K31/13 , A61K31/135 , A61K31/138 , A61K31/19 , A61K31/192 , A61K31/46 , A61K31/485 , A61K2300/00
摘要： Sustained-release oral pharmaceutical compositions and methods of use, wherein the compositions are in a single dosage form and include an amine-containing compound (including salts thereof), a salt of a non-steroidal anti-inflammatory drug (NSAID), and a hydrophilic matrix.
摘要翻译： 持续释放的口服药物组合物和使用方法，其中所述组合物为单一剂型，并且包括含胺化合物（包括其盐），非甾体抗炎药（NSAID）的盐和 亲水基质。
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公开(公告)号：US08362029B2
公开(公告)日：2013-01-29
申请号：US13142784
申请日：2009-12-31
申请人： Kenneth L. Evenstad , Christian F. Wertz , James S. Jensen , Victoria Ann O'Neill , Stephen M. Berge
发明人： Kenneth L. Evenstad , Christian F. Wertz , James S. Jensen , Victoria Ann O'Neill , Stephen M. Berge
CPC分类号： A61K9/2054 , A61K9/2013 , A61K31/10 , A61K31/135 , A61K31/19 , A61K31/192 , A61K31/439 , A61K31/485 , A61K2300/00
摘要： The present invention provides sustained-release oral pharmaceutical compositions and methods of use. The sustained-release oral pharmaceutical compositions include an opioid (including salts thereof) and a salt of a non-steroidal anti-inflammatory drug (NSAID).
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7.发明申请Sustained Release Composition Comprising an Amine as Active Agent and a Salt of a Cyclic Organic Acid 审中-公开包含作为活性剂的胺和环状有机酸的盐的持续释放组合物公开(公告)号：US20160051475A1
公开(公告)日：2016-02-25
申请号：US14851253
申请日：2015-09-11
IPC分类号： A61K9/20 , A61K31/135 , A61K31/485
CPC分类号： A61K9/2013 , A61K9/2054 , A61K31/135 , A61K31/137 , A61K31/192 , A61K31/485
摘要： The present invention provides sustained-release oral pharmaceutical compositions and methods of use. The sustained-release oral pharmaceutical compositions include an amine-containing compound (e.g., an opioid) (including salts thereof) and a pharmaceutically acceptable salt of a non-NSAID cyclic organic acid compound.
摘要翻译： 本发明提供持续释放的口服药物组合物和使用方法。 持续释放的口服药物组合物包括含有胺的化合物（例如阿片样物质）（包括其盐）和非NSAID环状有机酸化合物的药学上可接受的盐。
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8.发明申请公开(公告)号：US20120252833A1
公开(公告)日：2012-10-04
申请号：US13496818
申请日：2009-12-31
申请人： Christian F. Wertz , James S. Jensen , Victoria Ann O'Neill , Sean B. Mahoney , Stephen M. Berge
发明人： Christian F. Wertz , James S. Jensen , Victoria Ann O'Neill , Sean B. Mahoney , Stephen M. Berge
IPC分类号： A61K31/192 , A61K31/439 , A61P25/08 , A61P25/06 , A61P11/14 , A61K31/485 , A61P29/00
CPC分类号： A61K9/2054 , A61K9/2013 , A61K31/13 , A61K31/135 , A61K31/138 , A61K31/19 , A61K31/192 , A61K31/46 , A61K31/485 , A61K2300/00
摘要： Sustained-release oral pharmaceutical compositions and methods of use, wherein the compositions are in a single dosage form and include an amine-containing compound (including salts thereof), a salt of a non-steroidal anti-inflammatory drug (NSAID), and a hydrophilic matrix.
摘要翻译： 持续释放的口服药物组合物和使用方法，其中所述组合物为单一剂型，并且包括含胺化合物（包括其盐），非甾体抗炎药（NSAID）的盐和 亲水基质。
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