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公开(公告)号：US07018614B2
公开(公告)日：2006-03-28
申请号：US10865388
申请日：2004-06-10
申请人： Maxim Y. Kiselev , Vincent Tadino
发明人： Maxim Y. Kiselev , Vincent Tadino
CPC分类号： A61K51/0491
摘要： An 18F isotope-labeled FDG radiopharmaceutical is stabilized against degradation in radiochemical purity due to radiolysis using selected amounts of ethyl alcohol that depend on the activity concentration of the 18F with due regard to limits set by various pharmacopoeia standards. Any of the well-know production methods for the FDG may be used and the ethyl alcohol added at several stages, preferably as part of the standard hydrolysis step. This particular radiopharmaceutical is used extensively in diagnostic imaging with a Positron Emission Tomography technique.
摘要翻译： 通过使用选定量的乙醇进行放射化学分析，稳定抗原同位素标记的FDG放射性药物以降低放射化学纯度，该乙醇依赖于具有适当期限的“18”的活性浓度 考虑各种药典标准设定的限度。 可以使用任何熟知的FDG生产方法，并在几个阶段加入乙醇，优选作为标准水解步骤的一部分。 该特定放射性药物广泛用于具有正电子发射断层扫描技术的诊断成像。
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公开(公告)号：US20130030168A1
公开(公告)日：2013-01-31
申请号：US13632780
申请日：2012-10-01
CPC分类号： A61K51/1282 , A61K51/04 , A61K51/0491
摘要： The invention concerns a device for synthesis of radiopharmaceutical products based on chemical reagents contained in bottles, said device comprising several reaction compartments, transfer means between said bottles and said reaction compartments as well as mechanical means acting on said transfer means and enabling to monitor and control mechanically the transfer of chemical reagents. The invention is characterized in that it comprises: a fixed module including at least the mechanical means; a removable and disposable module, essentially in the shape of a support, whereon are arranged the transfer means between said bottles and said reaction compartments, said removable and disposable module not including any mechanical means; and means for securing said removable and disposable module to said fixed module.
摘要翻译： 本发明涉及一种用于合成基于瓶中所含化学试剂的放射性药物产品的装置，所述装置包括若干反应隔室，所述瓶和所述反应室之间的转移装置以及作用在所述转移装置上的机械装置，并且能够监测和控制 机械地转移化学试剂。 本发明的特征在于它包括：至少包括机械装置的固定模块; 基本上为支撑件形式的可拆卸和一次性模块，其中在所述瓶子和所述反作用隔间之间设置转移装置，所述可移除和一次性模块不包括任何机械装置; 以及用于将所述可移动和一次性模块固定到所述固定模块的装置。
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公开(公告)号：US08287819B2
公开(公告)日：2012-10-16
申请号：US10450308
申请日：2001-12-12
CPC分类号： A61K51/1282 , A61K51/04 , A61K51/0491
摘要： The invention concerns a device for synthesis of radiopharmaceutical products based on chemical reagents contained in bottles, said device comprising several reaction compartments, transfer means between said bottles and said reaction compartments as well as mechanical means acting on said transfer means and enabling to monitor and control mechanically the transfer of chemical reagents. The invention is characterized in that it comprises: a fixed module including at least the mechanical means; a removable and disposable module, essentially in the shape of a support, whereon are arranged the transfer means between said bottles and said reaction compartments, said removable and disposable module not including any mechanical means; and means for securing said removable and disposable module to said fixed module.
摘要翻译： 本发明涉及一种用于合成基于瓶中所含化学试剂的放射性药物产品的装置，所述装置包括若干反应隔室，所述瓶和所述反应室之间的转移装置以及作用在所述转移装置上的机械装置，并且能够监测和控制 机械地转移化学试剂。 本发明的特征在于它包括：至少包括机械装置的固定模块; 基本上为支撑件形式的可拆卸和一次性模块，其中在所述瓶子和所述反作用隔间之间设置转移装置，所述可移除和一次性模块不包括任何机械装置; 以及用于将所述可移动和一次性模块固定到所述固定模块的装置。
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公开(公告)号：US20050147535A1
公开(公告)日：2005-07-07
申请号：US10502983
申请日：2003-01-31
申请人： Seth Shulman , Alan Wilson , Michael Scardina , Michell Albers , Vincent Tadino
发明人： Seth Shulman , Alan Wilson , Michael Scardina , Michell Albers , Vincent Tadino
摘要： A system for radiolabeling compounds with a labeling module, which is fluidly connectable to a solvent delivery module, an HPLC pump and an HPLC column. The labeling module includes a loop and valves having different orientations to provide different fluid pathways of solvent, radiolabeling agent and inert gas through the system.
摘要翻译： 用于放射性标记化合物的系统，其具有可流体连接到溶剂递送模块，HPLC泵和HPLC柱的标记模块。 标签模块包括具有不同取向的回路和阀，以通过系统提供溶剂，放射性标记试剂和惰性气体的不同流体路径。
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