公开(公告)号：US08937188B2

公开(公告)日：2015-01-20

申请号：US13265854

申请日：2010-04-27

Applicant: Mubeen Ahmed Khan ,  Nikhil Rasiklal Trivedi ,  Nagan Nirmalan Kandasamy ,  Dayaghan Gangadhar Patil ,  Vipin Kumar Pandey ,  Sukumar Sinha

Inventor： Mubeen Ahmed Khan ,  Nikhil Rasiklal Trivedi ,  Nagan Nirmalan Kandasamy ,  Dayaghan Gangadhar Patil ,  Vipin Kumar Pandey ,  Sukumar Sinha

IPC: C07D207/04 ,  C07D207/08

CPC classification number: C07D207/08 ,  Y10T428/2982

Abstract: A solid crystalline form of 1-(2-[4-(6-methoxy-3,4-dihydronaphthalene-1-y) phenoxy]ethyl)pyrrolidine, and a preparing process thereof are provided. The aforesaid compound is a key intermediate in the synthesis of lasofoxifene. A process for preparing lasofoxifene, a process for purifying lasofoxifene tartrate, and a crystalline form of lasofoxifene tartrate are also provided.

Abstract translation: 提供1-（2- [4-（6-甲氧基-3,4-二氢萘-1-y）苯氧基]乙基）吡咯烷的固体结晶形式及其制备方法。 上述化合物是拉莫昔芬合成中的关键中间体。 还提供了制备拉索昔芬的方法，用于纯化酒石酸拉索昔芬的方法和酒石酸拉索昔芬的结晶形式。

公开(公告)号：US20120045648A1

公开(公告)日：2012-02-23

申请号：US13265854

申请日：2010-04-27

Applicant: Mubeen Ahmed Khan ,  Nikhil Rasiklal Trivedi ,  Nagan Nirmalan Kandasamy ,  Dayaghan Gangadhar Patil ,  Vipin Kumar Pandey

Inventor： Mubeen Ahmed Khan ,  Nikhil Rasiklal Trivedi ,  Nagan Nirmalan Kandasamy ,  Dayaghan Gangadhar Patil ,  Vipin Kumar Pandey

IPC: B32B5/16 ,  C07D295/088

CPC classification number: C07D207/08 ,  Y10T428/2982

Abstract: A solid crystalline form of 1-(2-[4-(6-methoxy-3,4-dihydronaphthalene-1-y) phenoxy]ethyl)pyrrolidine, and a preparing process thereof are provided. The aforesaid compound is a key intermediate in the synthesis of lasofoxifene. A process for preparing lasofoxifene, a process for purifying lasofoxifene tartrate, and a crystalline form of lasofoxifene tartrate are also provided.

Abstract translation: 提供1-（2- [4-（6-甲氧基-3,4-二氢萘-1-基）苯氧基]乙基）吡咯烷的固体结晶形式及其制备方法。 上述化合物是拉莫昔芬合成中的关键中间体。 还提供了制备拉索昔芬的方法，用于纯化酒石酸拉索昔芬的方法和酒石酸拉索昔芬的结晶形式。