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公开(公告)号：US20240109891A1
公开(公告)日：2024-04-04
申请号：US18280175
申请日：2022-03-01
发明人： Hongjian ZHANG , Jingjing JI , Peihua SUN
IPC分类号： C07D471/14 , C07D487/04
CPC分类号： C07D471/14 , C07D487/04
摘要： This application relates to novel heterotricyclic compounds and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with mammalian RAS (Rat sarcoma virus) family proteins.
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公开(公告)号：US20240109887A1
公开(公告)日：2024-04-04
申请号：US18280177
申请日：2022-03-01
发明人： Hongjian ZHANG , Jingjing JI , Peihua SUN
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： This application relates to novel substituted bicyclic aza-heterocycles and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with mammalian RAS (Rat sarcoma virus) family proteins.
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3.发明公开公开(公告)号：US20230279026A1
公开(公告)日：2023-09-07
申请号：US18111283
申请日：2023-02-17
发明人： Ping Chen , Hongjian Zhang , Fei Jiang , Peihua Sun
IPC分类号： C07D519/00
CPC分类号： C07D519/00
摘要： This application relates to novel bicyclic substituted sulfonylurea compounds and analogues, their manufacture, pharmaceutical compositions comprising them, and their use as medicaments for treating a disease associated with modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3, or inhibition of the activation of NLRP3 or related components of the inflammatory process.
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