Method of treating organism by biologically active compounds specifically delivered into mitochondria, pharmaceutical composition required for the use of the method and a compound applicable for this purpose
    2.
    发明授权
    Method of treating organism by biologically active compounds specifically delivered into mitochondria, pharmaceutical composition required for the use of the method and a compound applicable for this purpose 有权
    通过特异性递送至线粒体的生物活性化合物治疗生物体的方法,使用该方法所需的药物组合物和适用于该目的的化合物

    公开(公告)号:US09328130B2

    公开(公告)日:2016-05-03

    申请号:US11972437

    申请日:2008-01-10

    摘要: This invention relates to biology and medicine and, in particular, can be used in medicine to make a pharmaceutical composition for targeted delivery of biologically active substances into mitochondria, driven by proton electro-chemical potential in the mitochondria. This invention also relates to the method to affect an organism by the targeted delivery of biologically active compounds to mitochondria. The invention can be useful in treatment of diseases or disorders associated with not normal functioning of mitochondria, in particular diseases associated with increased production of free radicals and reactive oxygen species.

    摘要翻译: 本发明涉及生物学和医学,并且特别地可以用于药物中,以制备用于将生物活性物质靶向递送至线粒体的药物组合物,其由线粒体中的质子电化学势所驱动。 本发明还涉及通过将生物活性化合物靶向递送至线粒体来影响生物体的方法。 本发明可用于治疗与线粒体不正常功能相关的疾病或病症,特别是与增加的自由基和活性氧的产生有关的疾病。

    BELT CLASP (VARIANTS)
    4.
    发明申请
    BELT CLASP (VARIANTS) 审中-公开
    皮带CLASP(VARIANTS)

    公开(公告)号:US20140007387A1

    公开(公告)日:2014-01-09

    申请号:US14002846

    申请日:2012-03-21

    IPC分类号: A44B11/18

    摘要: In order to simplify the design and use of a belt clasp whilst at the same time increasing the reliability and maintaining the integrity of the belt, and ensuring the integrity of the chain in the event of increased, differently directed static and dynamic mechanical loads, and the possibility of use of the front surfaces of the chain as information carriers and design means, in the belt clasp, which comprises two interlocking parts in the form of a linkage and a buckle connected to the belt, the linkage is formed with an internal through-opening for the belt, with arcuate lateral projections and a gap between the arcuate lateral projections with a size equal to or greater than twice the thickness of the belt but less than the width of the belt, while the buckle is formed with a transverse width that is greater than the width of the internal through-opening for the belt in the linkage. Furthermore, the linkage is capable of attachment to a belt, a bag, a briefcase, a case, an instrument case, a load transfer or transportation means or to any other article requiring a temporary connection, while the linkage and the buckle comprise means for mutual fixing when the said linkage and buckle are closed, for example, the means which are in the form of a T-shaped projection arranged on the buckle and a T-shaped opening in the linkage, magnets, velcro fasteners, clips, snap locks or any other functionally similar mutual fixing means.

    摘要翻译: 为了简化皮带扣的设计和使用,同时增加了皮带的可靠性和保持皮带的完整性,并且在增加了不同方向的静态和动态机械载荷的情况下确保链的完整性,以及 使用链条的前表面作为信息载体和设计装置的可能性在带扣中包括两个连接形式的联锁部件和连接到皮带的带扣,连杆形成有内部通孔 打开皮带,具有弓形横向突起和弧形侧向突起之间的间隙,其尺寸等于或大于带的厚度的两倍,但小于带的宽度,而带扣形成为横向宽度 大于连杆中的带的内部通孔的宽度。 此外,连杆机构能够附接到皮带,袋子,公文包,箱子,仪器箱,负载转移或运输装置或任何其它需要临时连接的物品,而连接件​​和带扣包括用于 当所述连接件和带扣闭合时相互固定,例如,设置在带扣上的T形突起形式的装置和连接件中的T形开口,磁体,尼龙搭扣,夹子,卡锁 或任何其他功能上类似的相互固定装置。

    TIGHTLY THREADED JOINT FOR OIL FIELD PIPES
    5.
    发明申请
    TIGHTLY THREADED JOINT FOR OIL FIELD PIPES 审中-公开
    用于油田管道的轻微螺纹接头

    公开(公告)号:US20120119489A1

    公开(公告)日:2012-05-17

    申请号:US12955681

    申请日:2010-11-29

    IPC分类号: F16L15/00

    摘要: The invention relates to building and operating vertical, controlled, directional and horizontal holes of oil and gas fields with difficult operating conditions, and can be used for process casing pipes. The inventive tightly threaded joint for oil field pipes comprises male and female pipes with a conical thread and stop and sealing surfaces. The stop surfaces are brought into contact by the end surface of the male pipe and the mating end surface of the female pipe. The conical thread configuration has a negative angle along a bearing face. The height of thread of the male pipe is less than the height of thread of the female pipe. The end surfaces are designed so that the area thereof is equal to or greater than 60% of the pipe body. The invention makes it possible to increase the operational reliability and effectiveness of the tight joint and to minimize ecological risks.

    摘要翻译: 本发明涉及在操作条件困难的油气田的垂直,受控,定向和水平孔的建造和操作,可用于加工套管。 本发明用于油田管的紧密螺纹接头包括具有锥形螺纹和止动和密封表面的阳和阴管。 止动表面通过阳管的端面和阴管的配合端面接触。 锥形螺纹构造沿着支承面具有负角度。 公管螺纹的高度小于母管螺纹的高度。 端面设计成使其面积等于或大于管体的60%。 本发明可以提高紧密接头的运行可靠性和有效性,并尽量减少生态风险。

    Anti-inflammatory extract and agent and method for the production thereof
    6.
    发明授权
    Anti-inflammatory extract and agent and method for the production thereof 有权
    抗炎提取物及其制备方法

    公开(公告)号:US08092845B2

    公开(公告)日:2012-01-10

    申请号:US11719457

    申请日:2005-11-15

    IPC分类号: A61K36/906 A61K36/15

    摘要: The invention relates to the pharmaceutical industry, in particular to producing herbal remedy for integrally treating various inflammatory diseases. The inventive remedy comprises a dry Boswellia extract dissolved in the oil extract of Siberian stone pine seeds and Curcuma. The remedy can be used in the form of soft gelatine capsules for peroral administration, wherein lecithin, hydroxy-toluene butyl, alpha-tocopherol acetate, ascorbyl palmitate are added to the ready-for-use oil extract. The inventive method for producing said remedy consists in producing the oil extracts of Siberian stone pine seeds and Curcuma and in subsequently adding the dry Boswellia extract thereto.

    摘要翻译: 本发明涉及制药工业,特别涉及生产用于整体治疗各种炎性疾病的草药。 本发明的补救方法包括溶解在西伯利亚松松种子和姜黄油提取物中的干燥乳香提取物。 补救剂可以以用于口服给药的软明胶胶囊的形式使用,其中将卵磷脂,羟基 - 甲苯丁基,α-生育酚乙酸酯,抗坏血酸棕榈酸酯加入到即用型油提取物中。 用于产生所述补救措施的本发明的方法包括生产西伯利亚松松种子和姜黄的油提取物,随后将干燥的乳香提取物加入其中。

    METHOD OF STUDYING ROCK MASS PROPERTIES AND APPARATUS FOR THE IMPLEMENTATION THEREOF
    7.
    发明申请
    METHOD OF STUDYING ROCK MASS PROPERTIES AND APPARATUS FOR THE IMPLEMENTATION THEREOF 失效
    研究岩石物性的方法及其实施方法

    公开(公告)号:US20110156707A1

    公开(公告)日:2011-06-30

    申请号:US12981026

    申请日:2010-12-29

    IPC分类号: G01V3/18

    CPC分类号: G01V3/26

    摘要: The rock mass thermal excitation is performed by means of pumping the flush fluid through the wellbore using a tubing string, the flush fluid temperature differs from the rock mass temperature. Before the thermal excitation, during the thermal excitation and after the termination thereof differential electrical signals proportional to the well bore temperature difference are registered by at least one pair of the temperature transducers positioned along the wellbore axis. The distances between the transducers in the pairs and the number of pairs is selected in advance based on the required accuracy of the determination of the rock mass areas with different properties, minimum and maximum possible length of the rock mass areas identified and the nature and degree of the wellbore temperature noise. Differential electrical signals of the temperature transducers measured before the rock mass excitation start are compared with the differential electrical signals from the same temperature transducers measured during the thermal excitation and the differential electrical signals of different temperature transducers positioned along the wellbore are compared with one another. Based on the comparison results of the differential electrical signals the difference of different rock mass areas are characterized by their properties and the boundaries between the rock mass areas with different properties are identified.

    摘要翻译: 通过使用管柱将冲洗流体泵送通过井眼来进行岩体热激发,冲洗流体温度与岩体温度不同。 在热激励之前,在热激励期间和在其终止之后,通过沿着井筒轴定位的至少一对温度传感器记录与井筒温度差成比例的差分电信号。 基于所确定的具有不同性质,确定的岩石质量区域的最小和最大可能长度的岩石质量区域的所需精度以及所确定的岩石质量区域的性质和程度,预先选择成对中的换能器和对数之间的距离 的井筒温度噪声。 将在岩石质量激发开始之前测量的温度传感器的差分电信号与来自在热激发期间测量的相同温度换能器的差分电信号进行比较,并且沿着井眼定位的不同温度传感器的差分电信号彼此进行比较。 基于差分电信号的比较结果,不同岩体区域的差异以其性质为特征,确定了具有不同性质的岩体区域之间的边界。

    LIGHT MULTIPURPOSE AIRCRAFT
    8.
    发明申请
    LIGHT MULTIPURPOSE AIRCRAFT 审中-公开
    轻型多用途飞机

    公开(公告)号:US20100012767A1

    公开(公告)日:2010-01-21

    申请号:US12448511

    申请日:2006-12-25

    IPC分类号: B64C39/00 B64C1/00 F41A23/00

    CPC分类号: B64D1/04 B64D7/00 F41F3/06

    摘要: A light multi-purpose aircraft comprises a fuselage (1); a wing (2); a fin assembly (3); a landing gear (4); a main power plant (5); an auxiliary power plant (7); pylons (10); outboard suspension objects (9) arranged on the undersurface and at the ends of the wing (2); at least one outboard suspension object (9) being arranged on the undersurface of the wing (2) and at least one outboard suspension object (9) being arranged at each end of the wing (2); a gun mount (8) or a guidance and tracking mount arranged in the lower part of the fuselage (1); a controlling integrated complex of airborne electronic equipment (17) with an electric power supply system (16) and an armament control complex (19) incorporating an on-board electronic guidance and tracking system (20); a defense system (21); a multi-purpose control panel (22); a group interaction system (23); an armament control system (24) which are related to each other and to the controlling integrated complex of airborne electronic equipment (17) through a multiplexer information exchange channel; the armament control system (24) comprising a matching and logic unit (25); an emergency unloading unit (26); at least one data distribution and conversion unit (27); executive units (28); units for switching outboard suspension objects (29); a unit for switching a gun mount or guidance and tracking mount (30); components of the armament control system (24) being linked by a local channel of information exchange, the number of the executive units (28) and the units for switching outboard suspension objects (29) being consistent with the number of outboard suspension objects (9).

    摘要翻译: 轻型多用途飞机包括机身(1); 翼(2); 翅片组件(3); 起落架(4); 主要发电厂(5座); 辅助发电厂(7); 塔架(10); 布置在翼面(2)的下表面和末端的外侧悬挂物(9); 至少一个外侧悬挂物体(9)布置在机翼(2)的下表面上,并且至少一个外侧悬挂物体(9)布置在机翼(2)的每个端部处; 机架(1)的下部安装有枪架(8)或引导和跟踪座架; 机载电子设备(17)与电力供应系统(16)和装有车载电子引导和跟踪系统(20)的装备控制综合体(19)的控制集成复合体; 防务体系(21) 多用途控制面板(22); 组交互系统(23); 通过多路复用器信息交换通道相互关联的机载控制系统(24)和机载电子设备(17)的控制集成复合体; 所述装备控制系统(24)包括匹配和逻辑单元(25); 紧急卸载单元(26); 至少一个数据分配和转换单元(27); 执行单位(28); 用于切换外侧悬挂物体的装置(29); 用于切换枪支座或引导和跟踪座(30)的单元; 武装控制系统(24)的组件通过本地信息交换信道链接,执行单元(28)的数量和用于切换外侧悬挂物体(29)的单元与外侧悬挂物体(9)的数量一致 )。

    Method for operating a well jet device during repair and insulating operations and device for carrying out said method
    9.
    发明授权
    Method for operating a well jet device during repair and insulating operations and device for carrying out said method 失效
    在维修和绝缘操作期间操作井喷装置的方法和用于执行所述方法的装置

    公开(公告)号:US07090011B2

    公开(公告)日:2006-08-15

    申请号:US10485437

    申请日:2002-05-30

    IPC分类号: E21B47/12

    CPC分类号: F04F5/464 F04F5/10 F04F5/44

    摘要: The inventive method consists in the following: a drillable packer provided with a channel closed by a back valve is arranged in a well; afterwards a tubing string carrying a jet pump and a stinger is run into said well, the stringer being connected to the packer; the back valve is open; a logging instrument and a sealing unit are introduced into the tubing string with the aid of a cable; a depression is produced on the formation by means of the pump, a bottomhole pressure and the parameters of the formation are measured with the aid of said instrument, the parameters of physical fields being recorded. The results of said investigations being interpreted, the technical state of the well is defined. The instrument and the sealing unit being extracted from the tube string, a blocking insert is dropped therein. The tubing string is uplifted, the stringer is disconnected from the packer and the back valve is closed. A cement slurry being pumped into the tubing string, said tubing string is put down, the stringer is connected to the packer and the back valve is open. The cement slurry is pumped into the tail space, squeezed into the productive formation and the tubing string together with the pump and the stringer is extracted. The cement slurry being hardened, the packer is drilled out, the formation is perforated and the tubing string provided with a guiding cone, the packer and the pump is brought in the well. Said invention increases the reliability of the repair and insulating operations.

    摘要翻译: 本发明的方法包括以下:在井中布置设置有由后阀闭合的通道的可钻式封隔器; 之后,携带喷射泵和托管架的管柱进入所述井,纵梁连接到封隔器; 后阀打开; 借助于电缆将测井仪器和密封单元引入管柱中; 通过泵在地层上产生凹陷,借助于所述仪器测量井底压力和地层的参数,记录物理场的参数。 对所述调查的结果进行解释,确定井的技术状态。 仪器和密封单元从管柱中抽出,阻塞插入物落入其中。 油管柱升起,桁条与封隔器断开,后阀关闭。 将水泥浆泵入油管柱中,将油管柱放下,桁条与封隔器连接,后阀打开。 将水泥浆泵入尾部空间,挤入生产地层,并与泵一起提取管柱,并提取桁条。 水泥浆被硬化,封隔器被钻出,地层被穿孔,并且设置有引导锥体,封隔器和泵的管柱被带入井中。 所述发明增加了修理和绝缘操作的可靠性。