公开(公告)号：US06310033B1

公开(公告)日：2001-10-30

申请号：US09473503

申请日：1999-12-28

申请人： Alex R. Pagano ,  Walter C. Frank ,  Vrej Jubian

发明人： Alex R. Pagano ,  Walter C. Frank ,  Vrej Jubian

IPC分类号： A61K746

CPC分类号： C07C255/33 ,  C07C45/44 ,  C07C45/62 ,  C07C45/74 ,  C07C47/228 ,  C07C47/232

摘要： The use of substituted 5-phenylpentan-1-ols, 5-phenylpentanals, 5-phenylpentanitriles, 5-phenylpentanoic acid and lower alkyl esters thereof and 5-phenylpentanyl esters of C1-C6 aliphatic acids as fragrance materials is disclosed. The subject fragrance materials are, in large measure, novel compounds. The subject materials possess unique fragrance notes and are cost-effective materials.

摘要翻译： 公开了使用取代的5-苯基戊-1-醇，5-苯基戊醛，5-苯基戊腈，5-苯基戊酸及其低级烷基酯和C1-C6脂肪酸的5-苯基戊酯作为香料。 主题香料在很大程度上是新型化合物。 主题材料具有独特的香味，并且具有成本效益的材料。

公开(公告)号：US20060293341A1

公开(公告)日：2006-12-28

申请号：US11472826

申请日：2006-06-21

申请人： Vrej Jubian ,  Mathivanan Packiarajan ,  Hermogenes Jimenez ,  Emily Reinhard

发明人： Vrej Jubian ,  Mathivanan Packiarajan ,  Hermogenes Jimenez ,  Emily Reinhard

IPC分类号： A61K31/497 ,  A61K31/4439 ,  C07D417/02

CPC分类号： C07D417/04

摘要： This invention is directed to alkyl sulfonamide derivatives which are ligands at the NPY Y5 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression which comprises administering to the subject an amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from anxiety which comprises administering to the subject an amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject an amount of a compound of the subject invention.

摘要翻译： 本发明涉及作为NPY Y5受体的配体的烷基磺酰胺衍生物。 本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明还提供通过混合治疗有效量的本发明化合物和药学上可接受的载体制备的药物组合物。 本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。 本发明还提供了治疗患有抑郁症的受试者的方法，其包括给予受试者一定量的本发明化合物。 本发明还提供了治疗患有焦虑症的受试者的方法，其包括给予受试者一定量的本发明化合物。 本发明还提供了治疗患有肥胖症的受试者的方法，其包括给予受试者一定量的本发明化合物。

公开(公告)号：US20070213376A1

公开(公告)日：2007-09-13

申请号：US11714008

申请日：2007-03-05

申请人： Vrej Jubian ,  Mathivanan Packiarajan ,  Emily Reinhard

发明人： Vrej Jubian ,  Mathivanan Packiarajan ,  Emily Reinhard

IPC分类号： A61K31/44

CPC分类号： C07D417/04

摘要： This invention is directed to halogenated sulfonamide derivatives which are ligands at the NPY Y5 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression which comprises administering to the subject an amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from anxiety which comprises administering to the subject an amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject an amount of a compound of the subject invention. Furthermore, the present invention is directed to use of a compound of the invention for the manufacture of a medicament for treating a subject suffering from depression, anxiety or obesity.

摘要翻译： 本发明涉及作为NPY Y5受体的配体的卤代磺酰胺衍生物。 本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。 本发明还提供通过混合治疗有效量的本发明化合物和药学上可接受的载体制备的药物组合物。 本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。 本发明还提供了治疗患有抑郁症的受试者的方法，其包括给予受试者一定量的本发明化合物。 本发明还提供了治疗患有焦虑症的受试者的方法，其包括给予受试者一定量的本发明化合物。 本发明还提供了治疗患有肥胖症的受试者的方法，其包括给予受试者一定量的本发明化合物。 此外，本发明涉及本发明化合物在制备用于治疗患有抑郁，焦虑或肥胖的受试者的药物中的用途。

公开(公告)号：US20050192337A1

公开(公告)日：2005-09-01

申请号：US10637214

申请日：2003-08-07

申请人： Vrej Jubian ,  John Wetzel ,  Michael O'Neill

发明人： Vrej Jubian ,  John Wetzel ,  Michael O'Neill

IPC分类号： C07D209/40 ,  A61K31/404 ,  C07D209/36

CPC分类号： C07D209/40

摘要： This invention relates to crystalline forms, as well as an amorphous form of Compound I [1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-1H-indol-2-one], the processes for their preparation, compositions containing the same and the therapeutic use of such compositions. This invention further relates to a process for preparing Compound I.

摘要翻译： 本发明涉及结晶形式，以及化合物I [1-苯基-3 - [[3-（三氟甲基）苯基]亚氨基] -1H-吲哚-2-酮的无定形形式，其制备方法， 含有该组合物的组合物和这些组合物的治疗用途。 本发明还涉及一种制备化合物I的方法。