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1.发明授权Inhibition of excessive phospholipase A.sub.2 activity and/or production by non-antimicrobial tetracyclines 失效抑制过量磷脂酶A2活性和/或非抗微生物四环素生产
公开(公告)号：US5523297A
公开(公告)日：1996-06-04
申请号：US426899
申请日：1995-04-21
申请人： Waldemar Pruzanski , Lorne M. Golub , Peter Vadas , Robert A. Greenwald , Nangavarum S. Ramamurthy , Thomas F. McNamara
发明人： Waldemar Pruzanski , Lorne M. Golub , Peter Vadas , Robert A. Greenwald , Nangavarum S. Ramamurthy , Thomas F. McNamara
IPC分类号： A61K31/65
CPC分类号： A61K31/65
摘要： A method for treating mammals suffering from conditions associated with excess phospholipase A.sub.2 activity and/or production comprising administering to the mammal an effective amount of a non-antimicrobial tetracycline sufficient to inhibit excess phospholipase A.sub.2 activity and/or production is disclosed.
摘要翻译： 公开了一种治疗患有与过量磷脂酶A2活性和/或产物相关的病症的哺乳动物的方法，包括向哺乳动物施用有效量的足以抑制过量磷脂酶A2活性和/或产生的非抗微生物四环素。
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2.发明授权Antibodies that specifically bind to and inhibit human synovial phospholipase A.sub.2 type A 失效特异性结合并抑制人滑膜磷脂酶A2型A的抗体
公开(公告)号：US5552530A
公开(公告)日：1996-09-03
申请号：US283793
申请日：1994-08-01
摘要： Antibodies that specifically bind to and inhibit the enzymatic activity of synovial phospholipase A.sub.2 Type A are described. The antibodies may be used in assays for detection of synovial phospholipase A.sub.2 in biological samples.
摘要翻译： 描述了特异性结合并抑制滑膜磷脂酶A2型A的酶活性的抗体。 抗体可用于检测生物样品中滑膜磷脂酶A2的测定中。
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3.发明授权Inhibition of excessive phospholipase A.sub.2 activity and/or production by non-antimicrobial tetracyclines 失效抑制过量磷脂酶A2活性和/或非抗微生物四环素生产
公开(公告)号：US6043231A
公开(公告)日：2000-03-28
申请号：US115158
申请日：1993-08-31
申请人： Waldemar Pruzanski , Lorne M. Golub , Peter Vadas , Robert A. Greenwald , Nangavarum S. Ramamurthy , Thomas F. McNamara
发明人： Waldemar Pruzanski , Lorne M. Golub , Peter Vadas , Robert A. Greenwald , Nangavarum S. Ramamurthy , Thomas F. McNamara
IPC分类号： A61K31/65
CPC分类号： A61K31/65 , Y10S514/825 , Y10S514/863 , Y10S514/895
摘要： A method for treating mammals suffering from conditions associated with excess phospholipase A.sub.2 activity and/or production comprising administering to the mammal an effective amount of a non-antimicrobial tetracycline sufficient to inhibit excess phospholipase A.sub.2 activity and/or production is disclosed. A pharmaceutical composition is also disclosed.
摘要翻译： 公开了一种治疗患有与过量磷脂酶A2活性和/或产物相关的病症的哺乳动物的方法，包括向哺乳动物施用有效量的足以抑制过量磷脂酶A2活性和/或产生的非抗微生物四环素。 还公开了药物组合物。
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公开(公告)号：US5019508A
公开(公告)日：1991-05-28
申请号：US215726
申请日：1988-07-06
摘要： Mammalian synovial phospholipase A.sub.2 (sPLA.sub.2) enzymes are provided, as well as DNA constructs encoding these enzymes, methods of producing the enzymes recombinantly, and antibodies thereto. Therapeutic methods employing anti-synovial phospholipase antibodies are also provided, in addition to diagnositc methods and other applications of sPLA.sub.2.
摘要翻译： 提供哺乳动物滑膜磷脂酶A2（sPLA2）酶，以及编码这些酶的DNA构建体，重组产生酶的方法及其抗体。 除了sPLA2的诊断方法和其他应用之外，还提供了使用抗滑膜磷脂酶抗体的治疗方法。
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