公开(公告)号：US08759591B2

公开(公告)日：2014-06-24

申请号：US13517195

申请日：2011-06-03

申请人： Shuang Hu ,  Hao Chen ,  Zilin Ni ,  Wangshun Qi ,  Zhongying Chen ,  Zhiyuan Liu ,  Xudong Wang ,  Zhanyu Zhao ,  Weiqi Hua

发明人： Shuang Hu ,  Hao Chen ,  Zilin Ni ,  Wangshun Qi ,  Zhongying Chen ,  Zhiyuan Liu ,  Xudong Wang ,  Zhanyu Zhao ,  Weiqi Hua

IPC分类号： C07C209/00

CPC分类号： C07C209/72 ,  C07C209/86 ,  C07C2601/14 ,  C07C211/36

摘要： The present invention discloses a method for intermittently producing 4,4′-diaminodicyclohexyl methane (H12MDA) with a low amount of the trans-trans isomer thereof, which comprises: controlling the reaction process by stopping the reaction when, except for a solvent, the reaction solution comprises MDA of 0-5 wt % and H6MDA of 1-20 wt %; and b) separating the reaction solution obtained from step a) by conventional means to obtain H12MDA product with desired purity, and allowing the un-reacted material and intermediate product to be recycled to the reactor after being accumulated. The method of the present invention decreases the amount of the trans-trans isomer in H12MDA, increases the yield of the reaction, and reduces the production cost. The present invention also provides a post treatment process of the reaction mixture.

摘要翻译： 本发明公开了间歇地制备低反式异构体的4,4'-二氨基二环己基甲烷（H12MDA）的方法，该方法包括：除溶剂外，通过停止反应来控制反应过程 反应溶液包含0-5重量％的MDA和1-20重量％的H6MDA; 和b）通过常规方法分离由步骤a）获得的反应溶液以获得具有所需纯度的H12MDA产物，并且使未反应的材料和中间产物在积聚后再循环到反应器中。 本发明的方法降低了H12MDA中反式异构体的量，提高了反应的产率，降低了生产成本。 本发明还提供了反应混合物的后处理方法。

公开(公告)号：US20120323041A1

公开(公告)日：2012-12-20

申请号：US13517195

申请日：2011-06-03

申请人： Shuang Hu ,  Hao Chen ,  Zilin Ni ,  Wangshun Qi ,  Zhongying Chen ,  Zhiyuan Liu ,  Xudong Wang ,  Zhanyu Zhao ,  Weiqi Hua

发明人： Shuang Hu ,  Hao Chen ,  Zilin Ni ,  Wangshun Qi ,  Zhongying Chen ,  Zhiyuan Liu ,  Xudong Wang ,  Zhanyu Zhao ,  Weiqi Hua

IPC分类号： C07C209/00

CPC分类号： C07C209/72 ,  C07C209/86 ,  C07C2601/14 ,  C07C211/36

摘要： The present invention discloses a method for intermittently producing 4,4′-diaminodicyclohexyl methane (H12MDA) with a low amount of the trans-trans isomer thereof, which comprises: controlling the reaction process by stopping the reaction when, except for a solvent, the reaction solution comprises MDA of 0-5 wt % and H6MDA of 1-20 wt %; and b) separating the reaction solution obtained from step a) by conventional means to obtain H12MDA product with desired purity, and allowing the un-reacted material and intermediate product to be recycled to the reactor after being accumulated. The method of the present invention decreases the amount of the trans-trans isomer in H12MDA, increases the yield of the reaction, and reduces the production cost. The present invention also provides a post treatment process of the reaction mixture.

摘要翻译： 本发明公开了间歇地制备低反式异构体的4,4'-二氨基二环己基甲烷（H12MDA）的方法，该方法包括：除溶剂外，通过停止反应来控制反应过程 反应溶液包含0-5重量％的MDA和1-20重量％的H6MDA; 和b）通过常规方法分离由步骤a）获得的反应溶液以获得具有所需纯度的H12MDA产物，并且使未反应的材料和中间产物在积聚后再循环到反应器中。 本发明的方法降低了H12MDA中反式异构体的量，提高了反应的产率，降低了生产成本。 本发明还提供了反应混合物的后处理方法。