公开(公告)号：US20050260235A1

公开(公告)日：2005-11-24

申请号：US11096698

申请日：2005-03-31

申请人： Nancy Haigwood ,  Wendy Blay ,  Leonidas Stamatatos

发明人： Nancy Haigwood ,  Wendy Blay ,  Leonidas Stamatatos

IPC分类号： A61K39/00 ,  C07K14/16

CPC分类号： C07K14/005 ,  A61K2039/545 ,  C12N2740/16122

摘要： The invention provides vaccination protocols for administering immunogens to a primate host in order to promote the formation of neutralizing antibodies (NAbs) against primate immunodeficiency viruses. In some embodiments, the vaccination protocols comprise the step of administering to a primate host a first immunogen comprising at least one primate immunodeficiency virus Envelope (env) sequence having a first set of consensus glycosylation sequences, followed by a second immunogen comprising at least one primate immunodeficiency virus env sequence having a second set of consensus glycosylation sequences, wherein the differences between the first set of consensus glycosylation sequences and the second set of consensus glycosylation sequences comprise differences in consensus glycosylation sequences observed in HIV isolates obtained at different time points of a natural infection.

摘要翻译： 本发明提供了针对灵长类动物宿主施用免疫原的疫苗方案，以促进针对灵长类动物免疫缺陷病毒的中和抗体（NAb）的形成。 在一些实施方案中，疫苗接种方案包括向灵长类动物宿主施用包含至少一种具有第一组共有糖基化序列的灵长类动物免疫缺陷病毒包膜（env）序列的第一免疫原，随后是包含至少一种灵长类动物的第二免疫原 具有第二组共有糖基化序列的免疫缺陷病毒env序列，其中第一组共有糖基化序列和第二组共有糖基化序列之间的差异包括在天然的不同时间点获得的HIV分离物中观察到的一致性糖基化序列的差异 感染。

公开(公告)号：US20080267993A1

公开(公告)日：2008-10-30

申请号：US11713124

申请日：2007-03-02

申请人： Nancy L. Haigwood ,  Wendy Blay ,  Leonidas Stamatatos

发明人： Nancy L. Haigwood ,  Wendy Blay ,  Leonidas Stamatatos

IPC分类号： A61K39/295 ,  A61P31/18

CPC分类号： C07K14/005 ,  A61K2039/545 ,  C12N2740/16122

摘要： The invention provides vaccination protocols for administering immunogens to a primate host in order to promote the formation of neutralizing antibodies (NAbs) against primate immunodeficiency viruses. In some embodiments, the vaccination protocols comprise the step of administering to a primate host a first immunogen comprising at least one primate immunodeficiency virus Envelope (env) sequence having a first set of consensus glycosylation sequences, followed by a second immunogen comprising at least one primate immunodeficiency virus env sequence having a second set of consensus glycosylation sequences, wherein the differences between the first set of consensus glycosylation sequences and the second set of consensus glycosylation sequences comprise differences in consensus glycosylation sequences observed in HIV isolates obtained at different time points of a natural infection.

摘要翻译： 本发明提供了针对灵长类动物宿主施用免疫原的疫苗方案，以促进针对灵长类动物免疫缺陷病毒的中和抗体（NAb）的形成。 在一些实施方案中，疫苗接种方案包括给灵长类动物宿主施用包含至少一种具有第一组共有糖基化序列的灵长类动物免疫缺陷病毒包膜（env）序列的第一免疫原，随后是包含至少一种灵长类动物的第二免疫原 具有第二组共有糖基化序列的免疫缺陷病毒env序列，其中第一组共有糖基化序列和第二组共有糖基化序列之间的差异包括在天然的不同时间点获得的HIV分离物中观察到的一致性糖基化序列的差异 感染。