公开(公告)号：US06294680B1

公开(公告)日：2001-09-25

申请号：US09341809

申请日：2000-01-05

申请人： Ton Rene Vries ,  Hans Wijnberg ,  Wijnand Sjourd Faber ,  Venetka Ivanova Kalkman-Agayn ,  Mieke Ivanova Sibeyn

发明人： Ton Rene Vries ,  Hans Wijnberg ,  Wijnand Sjourd Faber ,  Venetka Ivanova Kalkman-Agayn ,  Mieke Ivanova Sibeyn

IPC分类号： C07D31906

CPC分类号： C07F5/025 ,  C07D309/30 ,  C07F9/65742

摘要： A process has been provided to produce semi synthetic statins, as for instance simvastatin with a high yield, for another statin, preferably a naturally occurring statin, as for instance lovastatin. Also a number of novel intermediate compounds, prepared during said process, has been provided.

摘要翻译： 已经提供了一种制备半合成他汀类药物的方法，例如具有高产率的辛伐他汀，另一种他汀类药物，优选天然的他汀类药物，如洛伐他汀。 还提供了在所述方法期间制备的许多新型中间体化合物。