公开(公告)号：US4131745A

公开(公告)日：1978-12-26

申请号：US852656

申请日：1977-11-18

申请人： Jean-Marie Ferland ,  Real Laliberte ,  Wilbur Lippman ,  Thomas A. Pugsley

发明人： Jean-Marie Ferland ,  Real Laliberte ,  Wilbur Lippman ,  Thomas A. Pugsley

IPC分类号： A61K31/135 ,  C07C233/16 ,  C07C103/38

CPC分类号： A61K31/135 ,  C07C233/16

摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.

公开(公告)号：US4244966A

公开(公告)日：1981-01-13

申请号：US78546

申请日：1979-09-24

申请人： Wilbur Lippman ,  Christopher A. Demerson ,  Leslie G. Humber ,  Jean-Marie Ferland

发明人： Wilbur Lippman ,  Christopher A. Demerson ,  Leslie G. Humber ,  Jean-Marie Ferland

IPC分类号： C07C207/04 ,  C07D209/46 ,  C07D275/06 ,  C07D307/88 ,  A61K31/40

CPC分类号： C07D275/06 ,  C07C207/04 ,  C07D209/46 ,  C07D307/88 ,  Y10S514/925

摘要： Derivatives of 1,3-dihydro-3-(2-hydroxyethyl) -2H-isoindol-1-one are disclosed. The derivatives are useful for treating ulcers in a mammal and for preventing or decreasing the secretion or availability of excessive amounts of gastric or hydrochloric acid in a mammal suffering from hyperchlorhydria and/or associated conditions.

摘要翻译： 公开了1,3-二氢-3-（2-羟乙基）-2H-异吲哚-1-酮的衍生物。 所述衍生物可用于治疗哺乳动物的溃疡，并且用于预防或减少患有高氯酸盐和/或相关病症的哺乳动物中过量的胃酸或盐酸的分泌或可用性。