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公开(公告)号：US20140255415A1
公开(公告)日：2014-09-11
申请号：US14280933
申请日：2014-05-19
申请人： Marta CORTES-CROS , Ingo Markus KLAGGE , Josef PRASSLER , Adrian Robert WALMSLEY , William Leonard WISHART
发明人： Marta CORTES-CROS , Ingo Markus KLAGGE , Josef PRASSLER , Adrian Robert WALMSLEY , William Leonard WISHART
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , A61K39/39533 , A61K2039/505 , C07K16/18 , C07K16/2803 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
摘要： The present invention provides a binding molecule which is capable of binding to the rat, cynomolgus monkey and human LINGO polypeptide, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment to promote axonal regeneration/plasticity; a pharmaceutical composition comprising said binding molecule; and a method of treatment of diseases associated with axonal degeneration and demyelination.
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公开(公告)号：US20140037639A1
公开(公告)日：2014-02-06
申请号：US14037841
申请日：2013-09-26
申请人： Marta CORTES-CROS , Ingo Markus KLAGGE , Josef PRASSLER , Adrian Robert WALMSLEY , William Leonard WISHART
发明人： Marta CORTES-CROS , Ingo Markus KLAGGE , Josef PRASSLER , Adrian Robert WALMSLEY , William Leonard WISHART
IPC分类号： C07K16/18
CPC分类号： C07K16/28 , A61K39/39533 , A61K2039/505 , C07K16/18 , C07K16/2803 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
摘要： The present invention provides a binding molecule which is capable of binding to the rat, cynomolgus monkey and human LINGO polypeptide, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment to promote axonal regeneration/plasticity; a pharmaceutical composition comprising said binding molecule; and a method of treatment of diseases associated with axonal degeneration and demyelination.
摘要翻译： 本发明提供能够结合大鼠，食蟹猴和人LINGO多肽的结合分子，其是编码这种结合分子的多核苷酸; 包含所述多核苷酸的表达载体; 包含能够产生结合分子的多核苷酸的表达系统; 包含如上所定义的表达系统的分离的宿主细胞; 使用这种结合分子作为药物，特别是在治疗中促进轴突再生/可塑性; 包含所述结合分子的药物组合物; 以及治疗与轴索变性和脱髓鞘相关的疾病的方法。
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公开(公告)号：US20080153768A1
公开(公告)日：2008-06-26
申请号：US11779098
申请日：2007-07-17
IPC分类号： A61K31/7052 , A61P25/00 , A61P35/00
CPC分类号： C12N15/1137 , A61K31/7052 , A61K31/713 , A61K38/00 , C12N15/1136 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/335 , C12N2310/3525
摘要： The present invention relates to methods to treat neurological disorders comprising intrathecal injection of an effective amount of a double-stranded (ds) RNA into a subject in need, wherein the dsRNA inhibits the expression of a target gene and to pharmaceutical compositions useful for such treatment.
摘要翻译： 本发明涉及治疗神经障碍的方法，包括鞘内注射有效量的双链（ds）RNA到需要的受试者，其中dsRNA抑制靶基因的表达和用于这种治疗的药物组合物 。
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公开(公告)号：US08129354B2
公开(公告)日：2012-03-06
申请号：US11779098
申请日：2007-07-17
CPC分类号： C12N15/1137 , A61K31/7052 , A61K31/713 , A61K38/00 , C12N15/1136 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/335 , C12N2310/3525
摘要： The present invention relates to methods to treat neurological disorders comprising intrathecal injection of an effective amount of a double-stranded (ds) RNA into a subject in need, wherein the dsRNA inhibits the expression of a target gene and to pharmaceutical compositions useful for such treatment.
摘要翻译： 本发明涉及治疗神经障碍的方法，包括鞘内注射有效量的双链（ds）RNA到需要的受试者，其中dsRNA抑制靶基因的表达和用于这种治疗的药物组合物 。
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公开(公告)号：US20120053230A1
公开(公告)日：2012-03-01
申请号：US13289334
申请日：2011-11-04
IPC分类号： A61K31/713 , A61P25/00 , A61P29/00
CPC分类号： C12N15/1137 , A61K31/7052 , A61K31/713 , A61K38/00 , C12N15/1136 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/335 , C12N2310/3525
摘要： The present invention relates to methods to treat neurological disorders comprising intrathecal injection of an effective amount of a double-stranded (ds) RNA into a subject in need, wherein the dsRNA inhibits the expression of a target gene and to pharmaceutical compositions useful for such treatment.
摘要翻译： 本发明涉及治疗神经障碍的方法，包括鞘内注射有效量的双链（ds）RNA到需要的受试者，其中dsRNA抑制靶基因的表达和用于这种治疗的药物组合物 。
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公开(公告)号：US08198259B2
公开(公告)日：2012-06-12
申请号：US13289334
申请日：2011-11-04
CPC分类号： C12N15/1137 , A61K31/7052 , A61K31/713 , A61K38/00 , C12N15/1136 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/335 , C12N2310/3525
摘要： The present invention relates to methods to treat neurological disorders comprising intrathecal injection of an effective amount of a double-stranded (ds) RNA into a subject in need, wherein the dsRNA inhibits the expression of a target gene and to pharmaceutical compositions useful for such treatment.
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公开(公告)号：US20100143362A1
公开(公告)日：2010-06-10
申请号：US12514542
申请日：2007-11-15
CPC分类号： C07K16/28 , A61K39/39533 , A61K2039/505 , C07K16/18 , C07K16/2803 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
摘要： The present invention provides a binding molecule which is capable of binding to the rat, cynomolgus monkey and human LINGO polypeptide, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment to promote axonal regeneration/plasticity; a pharmaceutical composition comprising said binding molecule; and a method of treatment of diseases associated with axonal degeneration and demyelination.
摘要翻译： 本发明提供能够结合大鼠，食蟹猴和人LINGO多肽的结合分子，其是编码这种结合分子的多核苷酸; 包含所述多核苷酸的表达载体; 包含能够产生结合分子的多核苷酸的表达系统; 包含如上所定义的表达系统的分离的宿主细胞; 使用这种结合分子作为药物，特别是在治疗中促进轴突再生/可塑性; 包含所述结合分子的药物组合物; 以及治疗与轴索变性和脱髓鞘相关的疾病的方法。
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公开(公告)号：US20130071400A1
公开(公告)日：2013-03-21
申请号：US13616226
申请日：2012-09-14
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/28 , A61K39/39533 , A61K2039/505 , C07K16/18 , C07K16/2803 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
摘要： The present invention provides a binding molecule which is capable of binding to the rat, cynomolgus monkey and human LINGO polypeptide, a polynucleotide encoding such binding molecule; an expression vector comprising said polynucleotide; an expression system comprising a polynucleotide capable of producing a binding molecule; an isolated host cell which comprises an expression system as defined above; the use of such binding molecule as a pharmaceutical, especially in the treatment to promote axonal regeneration/plasticity; a pharmaceutical composition comprising said binding molecule; and a method of treatment of diseases associated with axonal degeneration and demyelination.
摘要翻译： 本发明提供能够结合大鼠，食蟹猴和人LINGO多肽的结合分子，其是编码这种结合分子的多核苷酸; 包含所述多核苷酸的表达载体; 包含能够产生结合分子的多核苷酸的表达系统; 包含如上所定义的表达系统的分离的宿主细胞; 使用这种结合分子作为药物，特别是在治疗中促进轴突再生/可塑性; 包含所述结合分子的药物组合物; 以及治疗与轴索变性和脱髓鞘相关的疾病的方法。
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公开(公告)号：US08299221B2
公开(公告)日：2012-10-30
申请号：US12514542
申请日：2007-11-15
IPC分类号： A61K39/00
CPC分类号： C07K16/28 , A61K39/39533 , A61K2039/505 , C07K16/18 , C07K16/2803 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
摘要： The present invention provides a binding molecule which is capable of binding to the rat, cynomolgus monkey and human LINGO polypeptide, and a polynucleotide encoding the binding molecule. The invention also provides an expression vector comprising the polynucleotide, an expression system comprising a polynucleotide capable of producing a binding molecule, as well as an isolated host cell comprising the expression system for producing the binding molecule. The invention also provides for compositions comprising the LINGO binding molecules and the use of binding molecule compositions as a pharmaceutical, especially in the treatment to promote axonal regeneration/plasticity. The invention further provides for a method of treatment of diseases associated with axonal degeneration and demyelination.
摘要翻译： 本发明提供能够结合大鼠，食蟹猴和人LINGO多肽的结合分子和编码结合分子的多核苷酸。 本发明还提供了包含多核苷酸的表达载体，包含能够产生结合分子的多核苷酸的表达系统，以及包含用于产生结合分子的表达系统的分离的宿主细胞。 本发明还提供包含LINGO结合分子的组合物和结合分子组合物作为药物的用途，特别是在促进轴突再生/可塑性的治疗中。 本发明还提供了治疗与轴索变性和脱髓鞘相关的疾病的方法。
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