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1.发明授权Formulation of fast-dissolving efavirenz capsules or tablets using super-disintegrants 有权使用超级崩解剂配制快速溶解的依法韦仑胶囊或片剂公开(公告)号：US06555133B2
公开(公告)日：2003-04-29
申请号：US09824071
申请日：2001-04-02
IPC分类号： A61K920
CPC分类号： A61K31/536 , A61K9/1652 , A61K9/2054 , A61K9/2059 , Y10S514/885
摘要： The present invention provides improved oral dosage form formulations of efavirenz that are useful in the inhibition of human immunodeficiency virus (HIV), the prevention or treatment of infection by HIV, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS). In particular, the present invention relates to compressed tablets or capsules comprising efavirenz that contain one or more disintegrants that enhance the dissolution rate of the efavirenz in the gastrointestinal tract thereby improving the rate and extent of absorption of efavirenz in the body. The present invention also relates to the process of making such tablets or capsules.
摘要翻译： 本发明提供了可用于抑制人类免疫缺陷病毒（HIV），预防或治疗HIV感染和治疗所得到的获得性免疫缺陷综合征（AIDS）的依法韦仑的改进的口服剂型制剂。 特别地，本发明涉及包含依法韦仑的压片或胶囊，其包含一种或多种增强依法韦仑在胃肠道中的溶解速率的崩解剂，从而改善依法韦仑在体内的吸收速率和程度。 本发明还涉及制备这种片剂或胶囊剂的方法。
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公开(公告)号：US06238695B1
公开(公告)日：2001-05-29
申请号：US09286902
申请日：1999-04-06
IPC分类号： A61K920
CPC分类号： A61K31/536 , A61K9/1652 , A61K9/2054 , A61K9/2059 , Y10S514/885
摘要： The present invention provides improved oral dosage form formulations of efavirenz that are useful in the inhibition of human immunodeficiency virus (HIV), the prevention or treatment of infection by HIV, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS). In particular, the present invention relates to compressed tablets or capsules comprising efavirenz that contain one or more disintegrants that enhance the dissolution rate of the efavirenz in the gastrointestinal tract thereby improving the rate and extent of absorption of efavirenz in the body. The present invention also relates to the process of making such tablets or capsules.
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