公开(公告)号：US08486528B2

公开(公告)日：2013-07-16

申请号：US12355299

申请日：2009-01-16

申请人： Gi-yoong Tae ,  Won-il Choi ,  Ja-young Kim

发明人： Gi-yoong Tae ,  Won-il Choi ,  Ja-young Kim

IPC分类号： A61K9/14

CPC分类号： A61K47/34 ,  A61K9/5146 ,  A61K9/5192 ,  Y10T428/29 ,  Y10T428/2982

摘要： The present invention relates to a process of preparing a biocompatible temperature-sensitive nano-carrier, which comprises the steps of (a) preparing a polymer dispersion comprising a water-soluble biocompatible polymer with photo-crosslinkable functional group(s), (b) preparing a polymer-initiator solution by adding an initiator to the polymer dispersion, and (c) preparing the nano-carrier by irradiating light onto the polymer-initiator solution, wherein the average diameter of the nano-carrier changes depending on temperature, and also relates to a temperature-sensitive nano-carrier. Nano-carriers of the present invention are temperature-sensitive, and their average diameter and pore size reversibly change in response to temperature change. In an embodiment of the present invention, nano-carriers can be prepared via a one-pot single-phase synthesis. A process of the present invention overcomes the conventional problems such as the use of organic solvent, complicated preparation steps, a relatively high manufacture cost and a low loading efficiency. Moreover, a process of the present invention can ensure the stability of drugs without necessitating high-speed homogenization or ultrasonification generally carried out in the conventional process.

摘要翻译： 本发明涉及制备生物相容性温度敏感性纳米载体的方法，其包括以下步骤：（a）制备包含具有可光交联官能团的水溶性生物相容性聚合物的聚合物分散体，（b） 通过向聚合物分散体中加入引发剂制备聚合物引发剂溶液，和（c）通过将光照射到聚合物 - 引发剂溶液上制备纳米载体，其中纳米载体的平均直径根据温度而变化， 涉及一种温度敏感的纳米载体。 本发明的纳米载体是温度敏感的，并且它们的平均直径和孔径随温度变化而可逆地改变。 在本发明的一个实施方案中，可以通过一锅单相合成制备纳米载体。 本发明的方法克服了常规问题，例如使用有机溶剂，复杂的制备步骤，相对高的制造成本和低负载效率。 此外，本发明的方法可以确保药物的稳定性，而不需要通常在常规方法中进行的高速均化或超声波化。

公开(公告)号：US20130054929A1

公开(公告)日：2013-02-28

申请号：US13592923

申请日：2012-08-23

申请人： Kun Hoon BAIK ,  Woong Suk Cho ,  Won Il Choi ,  Jong Hoon Han

发明人： Kun Hoon BAIK ,  Woong Suk Cho ,  Won Il Choi ,  Jong Hoon Han

IPC分类号： G06F12/02

CPC分类号： G06F12/126

摘要： A mobile terminal and an operation method for the same based on memory state changes are provided. The operation method includes detecting a transition between memory states of a memory unit; performing operation control by placing and releasing memory usage restrictions on and from at least one of an application program previously loaded in the memory unit and an application program newly loaded in the memory unit based on the detected memory state transition.

摘要翻译： 提供了一种基于存储器状态变化的移动终端及其操作方法。 操作方法包括检测存储器单元的存储器状态之间的转变; 基于检测到的存储器状态转移，通过将先前加载到存储器单元中的应用程序和新加载到存储器单元中的应用程序中的至少一个放置和释放存储器使用限制来执行操作控制。

公开(公告)号：US20090196937A1

公开(公告)日：2009-08-06

申请号：US12355299

申请日：2009-01-16

申请人： Gi-yoong TAE ,  Won-il CHOI ,  Ja-young KIM

发明人： Gi-yoong TAE ,  Won-il CHOI ,  Ja-young KIM

IPC分类号： A61K9/14 ,  C08J3/28 ,  A61K38/38 ,  A61K33/24

CPC分类号： A61K47/34 ,  A61K9/5146 ,  A61K9/5192 ,  Y10T428/29 ,  Y10T428/2982

摘要： The present invention relates to a process of preparing a biocompatible temperature-sensitive nano-carrier, which comprises the steps of (a) preparing a polymer dispersion comprising a water-soluble biocompatible polymer with photo-crosslinkable functional group(s), (b) preparing a polymer-initiator solution by adding an initiator to the polymer dispersion, and (c) preparing the nano-carrier by irradiating light onto the polymer-initiator solution, wherein the average diameter of the nano-carrier changes depending on temperature, and also relates to a temperature-sensitive nano-carrier. Nano-carriers of the present invention are temperature-sensitive, and their average diameter and pore size reversibly change in response to temperature change. In an embodiment of the present invention, nano-carriers can be prepared via a one-pot single-phase synthesis. A process of the present invention overcomes the conventional problems such as the use of organic solvent, complicated preparation steps, a relatively high manufacture cost and a low loading efficiency. Moreover, a process of the present invention can ensure the stability of drugs without necessitating high-speed homogenization or ultrasonification generally carried out in the conventional process.

摘要翻译： 本发明涉及制备生物相容性温度敏感性纳米载体的方法，其包括以下步骤：（a）制备包含具有可光交联官能团的水溶性生物相容性聚合物的聚合物分散体，（b） 通过向聚合物分散体中加入引发剂制备聚合物引发剂溶液，和（c）通过将光照射到聚合物 - 引发剂溶液上制备纳米载体，其中纳米载体的平均直径根据温度而变化， 涉及一种温度敏感的纳米载体。 本发明的纳米载体是温度敏感的，并且它们的平均直径和孔径随温度变化而可逆地改变。 在本发明的一个实施方案中，可以通过一锅单相合成制备纳米载体。 本发明的方法克服了常规问题，例如使用有机溶剂，复杂的制备步骤，相对高的制造成本和低负载效率。 此外，本发明的方法可以确保药物的稳定性，而不需要通常在常规方法中进行的高速均化或超声波化。