公开(公告)号：US20080292685A1

公开(公告)日：2008-11-27

申请号：US12096545

申请日：2005-12-09

Applicant: Shuming Wang ,  Li Wang ,  Xiaoling Fan ,  Huiyong Xue ,  Shuang Zhang ,  Enhong Zhang ,  Xuying Zhong ,  Yucheng Lu ,  Chun Li ,  Li Song

Inventor： Shuming Wang ,  Li Wang ,  Xiaoling Fan ,  Huiyong Xue ,  Shuang Zhang ,  Enhong Zhang ,  Xuying Zhong ,  Yucheng Lu ,  Chun Li ,  Li Song

IPC: A61K9/70 ,  A61K31/343 ,  A61P9/00

CPC classification number: A61K9/7061 ,  A61K31/138 ,  A61K31/724

Abstract: This invention relates to a transdermal patch in the form of a layer complex, comprising a backing layer, a drug-reservoir layer comprising pharmacologically active ingredients and pharmaceutically acceptable adjuvants, and a release liner covering the drug-reservoir layer, characterized in that the drug-reservoir layer comprises isosorbide dinitrate and Bisoprolol at a ratio of 1:3 to 3:1 by weight, as the pharmacologically active ingredients. Animal tests show that said patch can reduce the elevation of T wave of cardiogram, the increase of the level of myocardial enzyme in blood serum, and the extension of the range of myocardial infarction caused by ligating the coronary artery in animals. Results show that said patch exhibits a considerable synergistic effect in the treatment of cardiovascular diseases and has good preventive and therapeutic effects on several adverse events on heart. In addition, the animal tests show that the patch according to the invention has a better pressure-reducing effect than the application of the patch containing only one of isosorbide dinitrate and Bisoprolol, and does not worsen the arrhythmia that is easily caused by the application of the patch containing only isosorbide dinitrate or Bisoprolol.

Abstract translation: 本发明涉及层复合物形式的透皮贴剂，其包含背衬层，包含药理活性成分和药学上可接受的佐剂的药物储库层，以及覆盖药物储库层的释放衬垫，其特征在于药物 作为药理活性成分，含有硝酸异山梨酯和比索洛尔，比例为1:3〜3:1。 动物试验表明，所述贴片可以降低心电图T波的升高，血清中心肌酶水平的升高，以及通过在动物中连接冠状动脉引起的心肌梗塞范围的延长。 结果表明，所述贴片在治疗心血管疾病方面具有相当大的协同效应，对心脏上的几种不良事件具有良好的预防和治疗作用。 此外，动物试验表明，根据本发明的贴剂具有比仅含有硝酸异山梨酯和比洛维罗之一的贴剂的施用更好的减压效果，并且不会使应用容易引起的心律失常恶化 该补丁仅含有硝酸异山梨酯或比索洛尔。

公开(公告)号：US08071125B2

公开(公告)日：2011-12-06

申请号：US12096545

申请日：2005-12-09

Applicant: Shuming Wang ,  Li Wang ,  Xiaoling Fan ,  Huiyong Xue ,  Shuang Zhang ,  Enhong Zhang ,  Xuying Zhong ,  Yucheng Lu ,  Chun Li ,  Li Song

Inventor： Shuming Wang ,  Li Wang ,  Xiaoling Fan ,  Huiyong Xue ,  Shuang Zhang ,  Enhong Zhang ,  Xuying Zhong ,  Yucheng Lu ,  Chun Li ,  Li Song

IPC: A61F13/00

CPC classification number: A61K9/7061 ,  A61K31/138 ,  A61K31/724

Abstract: This invention relates to a transdermal patch in the form of a layer complex, comprising a backing layer, a drug-reservoir layer comprising pharmacologically active ingredients and pharmaceutically acceptable adjuvants, and a release liner covering the drug-reservoir layer, characterized in that the drug-reservoir layer comprises isosorbide dinitrate and Bisoprolol at a ratio of 1:3 to 3:1 by weight, as the pharmacologically active ingredients. Animal tests show that said patch can reduce the elevation of T wave of cardiogram, the increase of the level of myocardial enzyme in blood serum, and the extension of the range of myocardial infarction caused by ligating the coronary artery in animals. Results show that said patch exhibits a considerable synergistic effect in the treatment of cardiovascular diseases and has good preventive and therapeutic effects on several adverse events on heart. In addition, the animal tests show that the patch according to the invention has a better pressure-reducing effect than the application of the patch containing only one of isosorbide dinitrate and Bisoprolol, and does not worsen the arrhythmia that is easily caused by the application of the patch containing only isosorbide dinitrate or Bisoprolol.

Abstract translation: 本发明涉及层复合物形式的透皮贴剂，其包含背衬层，包含药理活性成分和药学上可接受的佐剂的药物储库层，以及覆盖药物储库层的释放衬垫，其特征在于药物 作为药理活性成分，含有硝酸异山梨酯和比索洛尔，比例为1:3〜3:1。 动物试验表明，所述贴片可以降低心电图T波的升高，血清中心肌酶水平的升高，以及通过在动物中连接冠状动脉引起的心肌梗塞范围的延长。 结果表明，所述贴片在治疗心血管疾病方面具有相当大的协同效应，对心脏上的几种不良事件具有良好的预防和治疗作用。 此外，动物试验表明，根据本发明的贴剂具有比仅含有硝酸异山梨酯和比洛维罗之一的贴剂的施用更好的减压效果，并且不会使应用容易引起的心律失常恶化 该补丁仅含有硝酸异山梨酯或比索洛尔。