公开(公告)号：US20160369341A1

公开(公告)日：2016-12-22

申请号：US14970541

申请日：2015-12-16

申请人： Wen E ,  Qingmei Kong ,  Xiaojing Zhang ,  Hong Shao ,  Zhenguo Zhao ,  Shuping Liu ,  Maomao Li ,  Xinxia Tian

发明人： Wen E ,  Qingmei Kong ,  Xiaojing Zhang ,  Hong Shao ,  Zhenguo Zhao ,  Shuping Liu ,  Maomao Li ,  Xinxia Tian

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156

摘要： The present invention relates to a rs6311 test kit, which includes a probe, a primer, and a polymerase chain reaction solution, wherein said probe sequence is as follows: rs6311T-fam: CTGTGAGTGTCTGGC (SEQ. ID. NO. 1) and rs6311C-vic: CTGTGAGTGTCCGGC (SEQ. ID. NO. 2); and said primer sequence is as follows: rs6311-F: AGAGAGAACATAAATAAGGCTAGAAAACAGTA (SEQ. ID. NO. 3) and rs6311-R: CACTGTTGGCTTTGGATGGA (SEQ. ID. NO. 4). The test kit is used to determine genotype of a depression patient, in order to treat the depression patient with a combination of serotonin reuptake inhibitors (SSRI) and low dose risperidone. The actual dose of risperidone and the ratio between SSRIs and risperidone is determined by the genotype of the depression patient. The present invention determines human drug metabolism rate through a single nucleotide polymorphism and provides a platform to adjust the patient's treatment.

摘要翻译： 本发明涉及一种rs6311测试试剂盒，其包括探针，引物和聚合酶链反应溶液，其中所述探针序列如下：rs6311T-fam：CTGTGAGTGTCTGGC（SEQ ID NO：1）和rs6311C- vic：CTGTGAGTGTCCGGC（SEQ ID NO：2）; 并且所述引物序列如下：rs6311-F：AGAGAGAACATAAATAAGGCTAGAAAACAGTA（SEQ ID NO：3）和rs6311-R：CACTGTTGGCTTTGGATGGA（SEQ ID NO：4）。 测试试剂盒用于确定抑郁症患者的基因型，以便用5-羟色胺再摄取抑制剂（SSRI）和低剂量利培酮组合治疗抑郁症患者。 利培酮的实际剂量和SSRI和利培酮之间的比例由抑郁症患者的基因型决定。 本发明通过单核苷酸多态性测定人体药物代谢率，提供调整患者治疗的平台。

公开(公告)号：US20140162261A1

公开(公告)日：2014-06-12

申请号：US14091575

申请日：2013-11-27

申请人： Wen E. ,  Qingmei Kong ,  Xiaojing Zhang ,  Hong Shao ,  Zhenguo Zhao ,  Shuping Liu ,  Maomao Li ,  Xinxia Tian

发明人： Wen E. ,  Qingmei Kong ,  Xiaojing Zhang ,  Hong Shao ,  Zhenguo Zhao ,  Shuping Liu ,  Maomao Li ,  Xinxia Tian

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/156

摘要： The present invention relates to a rs6311 test kit, which includes a probe, a primer, and a polymerase chain reaction solution, wherein said probe sequence is as follows: rs6311T-fam: CTGTGAGTGTCTGGC (SEQ. ID. NO. 1) and rs6311C-vic: CTGTGAGTGTCCGGC (SEQ. ID. NO. 2); and said primer sequence is as follows: rs6311-F: AGAGAGAACATAAATAAGGCTAGAAAACAGTA (SEQ. ID. NO. 3) and rs6311-R: CACTGTTGGCTTTGGATGGA (SEQ. ID. NO. 4). The test kit is used to determine genotype of a depression patient, in order to treat the depression patient with a combination of serotonin reuptake inhibitors (SSRI) and low dose risperidone. The actual dose of risperidone and the ratio between SSRIs and risperidone is determined by the genotype of the depression patient. The present invention determines human drug metabolism rate through a single nucleotide polymorphism and provides a platform to adjust the patient's treatment.

摘要翻译： 本发明涉及一种rs6311测试试剂盒，其包括探针，引物和聚合酶链反应溶液，其中所述探针序列如下：rs6311T-fam：CTGTGAGTGTCTGGC（SEQ ID NO：1）和rs6311C- vic：CTGTGAGTGTCCGGC（SEQ ID NO：2）; 并且所述引物序列如下：rs6311-F：AGAGAGAACATAAATAAGGCTAGAAAACAGTA（SEQ ID NO：3）和rs6311-R：CACTGTTGGCTTTGGATGGA（SEQ ID NO：4）。 测试试剂盒用于确定抑郁症患者的基因型，以便用5-羟色胺再摄取抑制剂（SSRI）和低剂量利培酮组合治疗抑郁症患者。 利培酮的实际剂量和SSRI和利培酮之间的比例由抑郁症患者的基因型决定。 本发明通过单核苷酸多态性测定人体药物代谢率，提供调整患者治疗的平台。