公开(公告)号：US5580562A

公开(公告)日：1996-12-03

申请号：US168980

申请日：1993-12-17

申请人： Peter E. Lipsky ,  Xue L. Tao ,  Jian Cai

发明人： Peter E. Lipsky ,  Xue L. Tao ,  Jian Cai

IPC分类号： A61K31/365 ,  A61K31/44 ,  A61K31/565 ,  A61K36/00 ,  A61K36/37 ,  C12Q1/68 ,  A61K35/78 ,  C07D307/77 ,  C07D321/00

CPC分类号： A61K31/565 ,  A61K31/365 ,  A61K31/44 ,  A61K36/37 ,  Y10S514/885 ,  Y10S514/908

摘要： A Tripterygium wilfordii Hook F preparation having an improved LD.sub.50 in mice, an improved therapeutic activity:toxic index ratio and a lower amount of triptolide as compared to previous preparations is disclosed. The LD.sub.50 in mice of the T. wilfordii preparation is greater than about 860 mg/kg, the therapeutic activity:toxic index ratio is greater than about 2.6.times.10.sup.-3, and the amount of triptolide is less than about 1.3 .mu.g/mg. The preparation is useful for immunosuppression, in particular, the suppression of primary antibody response and suppression of autoimmune disease and for the treatment of rheumatoid arthritis.

摘要翻译： 公开了具有改进的小鼠LD50的雷公藤钩藤F制剂，改善的治疗活性：与以前的制剂相比毒性指数比和较少量的雷公藤内酯。 T.wilfordii制剂小鼠中的LD50大于约860mg / kg，治疗活性：毒性指数比大于约2.6×10 -3，雷公藤内酯的量小于约1.3μg/ mg。 该制剂可用于免疫抑制，特别是抑制一级抗体应答和抑制自身免疫性疾病以及治疗类风湿性关节炎。