公开(公告)号：US20050118293A1

公开(公告)日：2005-06-02

申请号：US10972986

申请日：2004-10-25

申请人： Robert Gow ,  George Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger Marentis

发明人： Robert Gow ,  George Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger Marentis

IPC分类号： A23F3/36 ,  A61K36/00 ,  A61K36/185 ,  A61K35/78

CPC分类号： A61K36/185

摘要： The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making maté compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native maté plant materials. Further, the invention comprises methods of additional processing steps to produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.

摘要翻译： 本发明包括用于制备衍生自具有降低的咖啡因和单宁浓度的Ilex种，特别是白僵菌的组合物的组合物的方法，通过这些方法制备的组合物，口服递送制剂和使用该组合物的方法。 特别地，本发明包括与天然植物材料相比制备具有预定特征的，例如降低量的咖啡因，升高的咖啡因量和/或降低量的单宁化合物的方法。 此外，本发明包括另外的加工步骤的方法，以生产具有预定生物碱比例或轮廓的组合物以满足最终产品的特定考虑。 本发明的组合物可以用于特定用途，例如片剂或其它口服递送载体。 这些组合物可用于治疗生理和医学状况的方法。

公开(公告)号：US07294353B2

公开(公告)日：2007-11-13

申请号：US10970017

申请日：2004-10-21

申请人： Robert T. Gow ,  George W. Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger M. Marentis

发明人： Robert T. Gow ,  George W. Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger M. Marentis

IPC分类号： A61K36/00

CPC分类号： A61K36/185

摘要： The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making maté compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native maté plant materials. Further, the invention comprises methods of additional processing steps tp produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.

摘要翻译： 本发明包括用于制备衍生自具有降低的咖啡因和单宁浓度的Ilex种，特别是白僵菌的组合物的组合物的方法，通过这些方法制备的组合物，口服递送制剂和使用该组合物的方法。 特别地，本发明包括与天然植物材料相比制备具有预定特征的，例如降低量的咖啡因，升高的咖啡因量和/或降低量的单宁化合物的方法。 此外，本发明包括附加处理步骤的方法，tp产生具有预定生物碱比例或分布的组合物以满足最终产品的特定考虑。 本发明的组合物可以用于特定用途，例如片剂或其它口服递送载体。 这些组合物可用于治疗生理和医学状况的方法。

公开(公告)号：US07279184B2

公开(公告)日：2007-10-09

申请号：US10972986

申请日：2004-10-25

申请人： Robert T. Gow ,  George W. Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger M. Marentis

发明人： Robert T. Gow ,  George W. Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger M. Marentis

IPC分类号： A61K36/00

CPC分类号： A61K36/185

摘要： The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making maté compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native maté plant materials. Further, the invention comprises methods of additional processing steps to produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.

摘要翻译： 本发明包括用于制备衍生自具有降低的咖啡因和单宁浓度的Ilex种，特别是白僵菌的组合物的组合物的方法，通过这些方法制备的组合物，口服递送制剂和使用该组合物的方法。 特别地，本发明包括与天然植物材料相比制备具有预定特征的，例如降低量的咖啡因，升高的咖啡因量和/或降低量的单宁化合物的方法。 此外，本发明包括另外的加工步骤的方法，以生产具有预定生物碱比例或轮廓的组合物以满足最终产品的特定考虑。 本发明的组合物可以用于特定用途，例如片剂或其它口服递送载体。 这些组合物可用于治疗生理和医学状况的方法。

公开(公告)号：US20070065526A1

公开(公告)日：2007-03-22

申请号：US11229792

申请日：2005-09-19

申请人： Robert Gow ,  George Sypert ,  Dan Li ,  Xun Yan

发明人： Robert Gow ,  George Sypert ,  Dan Li ,  Xun Yan

IPC分类号： A61K36/254 ,  A61K31/704

CPC分类号： A61K36/258 ,  A61K31/704

摘要： The present invention comprises compositions comprising essential oils, ginsenosides, and polysaccharides. The present invention comprises methods comprising sequential solvent extraction and polymer absorbent purification to obtain fractions comprising essential oils, ginsenosides, and polysaccharides. The compositions of the present invention may be used in forms such as tablets, gel caps, or fast-dissolve tablets for use as dietary supplements or pharmaceutical compositions. The compositions of the present invention may be used for treatment of cardiovascular diseases, neurodegenerative diseases, inflammatory diseases, hepatic disorders, viral diseases, and cancer.

摘要翻译： 本发明包括包含精油，人参皂苷和多糖的组合物。 本发明包括顺序溶剂萃取和聚合物吸收性纯化以获得包含精油，人参皂苷和多糖的级分的方法。 本发明的组合物可以以用作膳食补充剂或药物组合物的形式使用，例如片剂，凝胶帽或快速溶解片剂。 本发明的组合物可用于治疗心血管疾病，神经退行性疾病，炎性疾病，肝病，病毒性疾病和癌症。

公开(公告)号：US20050089591A1

公开(公告)日：2005-04-28

申请号：US10970017

申请日：2004-10-21

申请人： Robert Gow ,  George Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger Marentis

发明人： Robert Gow ,  George Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger Marentis

IPC分类号： A23F3/00 ,  A61K31/522 ,  A61K36/00 ,  A61K36/185 ,  A61K35/78

CPC分类号： A61K36/185

摘要： The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making maté compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native maté plant materials. Further, the invention comprises methods of additional processing steps tp produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.

摘要翻译： 本发明包括用于制备衍生自具有降低的咖啡因和单宁浓度的Ilex种，特别是白僵菌的组合物的组合物的方法，通过这些方法制备的组合物，口服递送制剂和使用该组合物的方法。 特别地，本发明包括与天然植物材料相比制备具有预定特征的，例如降低量的咖啡因，升高的咖啡因量和/或降低量的单宁化合物的方法。 此外，本发明包括附加处理步骤的方法，tp产生具有预定生物碱比例或分布的组合物以满足最终产品的特定考虑。 本发明的组合物可以用于特定用途，例如片剂或其它口服递送载体。 这些组合物可用于治疗生理和医学状况的方法。