公开(公告)号：US20060292246A1

公开(公告)日：2006-12-28

申请号：US11471240

申请日：2006-06-20

申请人： Rey-Yuh Wu ,  Yuh-Shan Chung ,  Ya-Wen Kuo

发明人： Rey-Yuh Wu ,  Yuh-Shan Chung ,  Ya-Wen Kuo

IPC分类号： G01N33/00 ,  A61K36/18

CPC分类号： G01N30/8675 ,  G01N30/7266 ,  G01N30/8686 ,  G01N2030/8813

摘要： A characteristic mass spectral fingerprint setting method and a rapid identification method for Chinese herbal medicines or prescriptions are provided, which comprise directly injecting extracts of Chinese herbal medicines or prescriptions into a mass spectrometer with an electrospray ionization interface via an autosampler of a liquid chromatograph without going through a separation column to make a mass spectrum analysis; performing a series of mass spectrum analyses for various Chinese herbal medicines or prescription extracts; picking out the mass spectrum peaks representing the features of each of the Chinese herbal medicines or prescriptions as respective characteristic mass spectral fingerprints to establish a characteristic mass spectral fingerprint database of the Chinese herbal medicine or prescription; directly injecting an extract of the Chinese herbal medicines or prescription to be tested into a mass spectrometer with an electrospray ionization interface to make a mass spectrum analysis; and comparing and analyzing the obtained mass spectrum data with the characteristic mass spectral fingerprint database so as to rapidly identify the Chinese herbal medicine or prescription to be tested.

摘要翻译： 提供中药材或处方的特征质谱指纹设定方法和快速鉴定方法，其中包括通过液相色谱仪的自动进样器将中草药或处方的提取物直接注入带有电喷雾离子化界面的质谱仪，无需去 通过分离柱进行质谱分析; 对各种中草药或处方提取物进行一系列质谱分析; 挑选代表每种中药材或处方特征的质谱峰作为各自的特征质谱指纹，建立中草药或处方的特征质谱指纹数据库; 直接将中草药提取物或处方用电喷雾离子化界面进行质谱分析，进行质谱分析; 并利用特征质谱指纹数据库对获得的质谱数据进行比较分析，从而快速鉴定中草药或处方。