公开(公告)号：US20080057587A1

公开(公告)日：2008-03-06

申请号：US11469801

申请日：2006-09-01

Applicant: Dirk Mayer ,  Yakir Levin ,  Daniel Spielman ,  Ralph Eugene Hurd

Inventor： Dirk Mayer ,  Yakir Levin ,  Daniel Spielman ,  Ralph Eugene Hurd

IPC: G01N33/00

CPC classification number: G01R33/485 ,  G01R33/5601 ,  Y10T436/24

Abstract: A method of imaging the individual components of systems with sparse spectra using magnetic resonance imaging including the steps of a) exciting nuclei of labeled components using a MRI pulse sequence, b) selecting a proper spectral window to avoid/minimize signal overlap of aliased frequency components. In step a) preferably a spiral chemical shift imaging (spCSI) sequence is employed. In a preferred embodiment, hyperpolarized nuclei of 13C are used for labeling in a pyruvate substrate with metabolites of lacatate, alanine, and bicarbonate.

Abstract translation: 使用磁共振成像对具有稀疏光谱的系统的各个部件成像的方法，包括以下步骤：a）使用MRI脉冲序列激励标记分量的核; b）选择适当的光谱窗口以避免/最小化混叠频率分量的信号重叠 。 在步骤a）中优选使用螺旋化学位移成像（spCSI）序列。 在优选的实施方案中，13 C的超极化核用于在丙酮酸底物中用lacatate，丙氨酸和碳酸氢盐的代谢物进行标记。

公开(公告)号：US07709266B2

公开(公告)日：2010-05-04

申请号：US11469801

申请日：2006-09-01

Applicant: Dirk Mayer ,  Yakir Levin ,  Daniel Spielman ,  Ralph Eugene Hurd

Inventor： Dirk Mayer ,  Yakir Levin ,  Daniel Spielman ,  Ralph Eugene Hurd

IPC: G01N24/00

CPC classification number: G01R33/485 ,  G01R33/5601 ,  Y10T436/24

Abstract: A method of imaging the individual components of systems with sparse spectra using magnetic resonance imaging including the steps of a) exciting nuclei of labeled components using a MRI pulse sequence, b) selecting a proper spectral window to avoid/minimize signal overlap of aliased frequency components. In step a) preferably a spiral chemical shift imaging (spCSI) sequence is employed. In a preferred embodiment, hyperpolarized nuclei of 13C are used for labeling in a pyruvate substrate with metabolites of lacatate, alanine, and bicarbonate.

Abstract translation: 使用磁共振成像对具有稀疏光谱的系统的各个部件成像的方法，包括以下步骤：a）使用MRI脉冲序列激励标记分量的核; b）选择适当的光谱窗口以避免/最小化混叠频率分量的信号重叠 。 在步骤a）中优选使用螺旋化学位移成像（spCSI）序列。 在优选的实施方案中，13C的超极化核用于在丙酮酸底物中用lacatate，丙氨酸和碳酸氢盐的代谢物进行标记。