公开(公告)号：US6005113A

公开(公告)日：1999-12-21

申请号：US856422

申请日：1997-05-14

Applicant: Yexin Wu ,  Dieter H. Klaubert ,  Hee Chol Kang ,  Yu-Zhong Zhang

Inventor： Yexin Wu ,  Dieter H. Klaubert ,  Hee Chol Kang ,  Yu-Zhong Zhang

IPC: C09B57/10 ,  C09K11/06 ,  C09K3/00 ,  C09K11/02 ,  G01N33/546

CPC classification number: C09B57/10 ,  C09K11/06 ,  Y10S436/805

Abstract: The invention relates to fluorescent dyes that are substituted or unsubstituted derivatives of 1-(isoindolyl)methylene-isoindole that are bound through both isoindole nitrogens to a boron difluoride moiety, forming a fluorescent dibenzopyrrometheneboron difluoride compound ##STR1## that is further substituted by bathochromic substituents that are aryl or heteroaryl moieties further substituted by an additional aryl or heteroaryl, that is itself optionally further substituted by an additional aryl or heteroaryl. These aryl and heteroaryl groups are separated by a covalent bond, or by an ethenyl, butadienyl or hexatrienyl linkage. The dyes of the invention are particularly useful as labels for carriers, particularly polymeric microparticles. The resulting microparticles have a long-wavelength fluorescence emission, and possess utility for tracing flow in biological systems, particularly in tracing blood flow.

Abstract translation: 本发明涉及通过两个异吲哚氮结合到二氟化硼部分的1-（异吲哚基）亚甲基 - 异吲哚的取代或未取代的衍生物，形成荧光二苯并吡咯并噻唑二氟化物化合物，其进一步被作为芳基的红移取代基取代 或进一步被另外的芳基或杂芳基取代的杂芳基，其本身任选进一步被另外的芳基或杂芳基取代。 这些芳基和杂芳基通过共价键或乙烯基，丁二烯基或己三烯基键分离。 本发明的染料特别可用作载体，特别是聚合物微粒的标签。 所得微粒具有长波长荧光发射，并且具有用于追踪生物系统中的流动的效用，特别是在追踪血流中。