公开(公告)号：US20120295288A1

公开(公告)日：2012-11-22

申请号：US13475658

申请日：2012-05-18

申请人： Jau-Song Yu ,  Ya-Ting Chang ,  Chih-Ching Wu ,  Yi-Ming Shyr ,  Yu-Sun Chang

发明人： Jau-Song Yu ,  Ya-Ting Chang ,  Chih-Ching Wu ,  Yi-Ming Shyr ,  Yu-Sun Chang

IPC分类号： G01N33/574 ,  H01J49/26 ,  G01N27/62

CPC分类号： G01N33/57438

摘要： UL16 binding protein 2 (ULBP2) is a protein overexpressed in pancreatic cancer tissues, and the ULBP2 levels are significantly higher in pancreatic cancer patients than those in healthy controls. This invention provides a method to detect pancreatic cancer using ULBP2 as a serological marker. The combination of ULBP2 and CA19-9 promotes the efficacy of pancreatic cancer detection. When measuring the blood ULBP2 levels in patients with other cancer types, including colorectal carcinoma, nasopharyngeal carcinoma and gastric cancer illustrates the blood ULBP2 levels are higher in patients with pancreatic cancer than other cancer types.

摘要翻译： UL16结合蛋白2（ULBP2）是胰腺癌组织中过表达的蛋白质，胰腺癌患者的ULBP2水平明显高于健康对照组。 本发明提供了使用ULBP2作为血清学标记来检测胰腺癌的方法。 ULBP2和CA19-9的组合促进胰腺癌检测的功效。 当测量其他癌症类型（包括结肠直肠癌，鼻咽癌和胃癌）患者的血液ULBP2水平时，说明胰腺癌患者的血液ULBP2水平高于其他癌症类型。