公开(公告)号：US08071637B2

公开(公告)日：2011-12-06

申请号：US12440331

申请日：2007-09-10

Applicant: Yingping Guo ,  Genhui Chen ,  Bin Li

Inventor： Yingping Guo ,  Genhui Chen ,  Bin Li

IPC: C07D513/04 ,  A61K31/407

CPC classification number: C07D495/04

Abstract: The present invention provides dithiolopyrrolone compounds of the general formula I, and their salts, wherein A is sulfur or carbon, and R1, R2, and R3 are selected from groups defined herein, and wherein when A is sulfur, then B is oxygen, and n=1 or 2, and when A is carbon, then B is oxygen or sulfur, and n=1. The compounds are useful for the prevention and treatment of microbial infections such as HIV infection, and for the treatment of blood disorders, such as neutropenia. In particular, the compounds are useful for the manufacture of medicaments for increasing white blood cells.

Abstract translation: 本发明提供通式I的二硫代环吡咯酮化合物及其盐，其中A为硫或碳，R1，R2和R3选自本文定义的基团，其中当A为硫时，B为氧， n = 1或2，当A为碳时，B为氧或硫，n = 1。 这些化合物可用于预防和治疗诸如HIV感染的微生物感染，以及用于治疗血液病症，例如中性白细胞减少症。 特别地，这些化合物可用于制备用于增加白细胞的药物。

公开(公告)号：US20100041729A1

公开(公告)日：2010-02-18

申请号：US12440331

申请日：2007-09-10

Applicant: Yingping Guo ,  Genhui Chen ,  Bin Li

Inventor： Yingping Guo ,  Genhui Chen ,  Bin Li

IPC: A61K31/407 ,  C07D495/04

CPC classification number: C07D495/04

Abstract: The present invention provides dithiolopyrrolone compounds of the general formula I, and their salts, wherein A is sulfur or carbon, and R1, R2, and R3 are selected from groups defined herein, and wherein when A is sulfur, then B is oxygen, and n=1 or 2, and when A is carbon, then B is oxygen or sulfur, and n=1. The compounds are useful for the prevention and treatment of microbial infections such as HIV infection, and for the treatment of blood disorders, such as neutropenia. In particular, the compounds are useful for the manufacture of medicaments for increasing white blood cells.

Abstract translation: 本发明提供通式I的二硫代环吡咯酮化合物及其盐，其中A为硫或碳，R1，R2和R3选自本文定义的基团，其中当A为硫时，B为氧， n = 1或2，当A为碳时，B为氧或硫，n = 1。 这些化合物可用于预防和治疗诸如HIV感染的微生物感染，以及用于治疗血液病症，例如中性白细胞减少症。 特别地，这些化合物可用于制备用于增加白细胞的药物。