公开(公告)号：US20100099676A1

公开(公告)日：2010-04-22

申请号：US12447743

申请日：2007-10-31

申请人： Takeshi Endoh ,  Yasuhiko Fujii ,  Eiichi Kojima ,  Genta Tadano ,  Naoko Yamaguchi ,  Yo Adachi ,  Sachie Tagashira ,  Yuki Tachibana ,  Naohiro Onodera

发明人： Takeshi Endoh ,  Yasuhiko Fujii ,  Eiichi Kojima ,  Genta Tadano ,  Naoko Yamaguchi ,  Yo Adachi ,  Sachie Tagashira ,  Yuki Tachibana ,  Naohiro Onodera

IPC分类号： A61K31/5377 ,  C07D417/10 ,  A61K31/497 ,  C07D413/14 ,  C07D401/02 ,  C07D413/02 ,  A61K31/4965 ,  C07D241/04

CPC分类号： C07D209/86 ,  C07D211/96 ,  C07D213/81 ,  C07D215/20 ,  C07D241/04 ,  C07D243/08 ,  C07D263/32 ,  C07D277/28 ,  C07D295/22 ,  C07D295/26 ,  C07D307/81 ,  C07D307/91

摘要： A compound represented by the general formula (I): wherein R1 is wherein R26 and R28 are each independently lower alkyloxy and the like; n1 is an integer of 0 to 3; Z is a optionally substituted C1-C5 alkynylene which may be interrupted with a substituent selected from Substituent group a and the like; A is a group represented by the formula: wherein R6 and R7 are each independently lower alkyl and the like; m and n are each independently 0, 1, or 2; R2 is a hydrogen atom and the like; R3 is optionally substituted lower alkyl and the like; R4 is a hydrogen atom; or R3 and R4 may be taken together with an adjacent carbon atom to from a ring; R5 is hydroxyl and the like, or an optically active isomer, a pharmaceutically acceptable salt or a solvate thereof.

摘要翻译： 由通式（I）表示的化合物：其中R 1是其中R 26和R 28各自独立地为低级烷氧基等; n1为0〜3的整数， Z是可以被选自取代基组a等的取代基中断的任选取代的C 1 -C 5亚炔基; A是由下式表示的基团：其中R6和R7各自独立地为低级烷基等; m和n各自独立地为0,1或2; R2是氢原子等; R3是任选取代的低级烷基等; R4是氢原子; 或者R 3和R 4可以与相邻的碳原子一起与环一起取代; R5是羟基等，或光学活性异构体，其药学上可接受的盐或溶剂化物。