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1.发明授权Establishment of motif comprising acidic amino acid, capable of stabilizing protein in cells, and applicable to protein therapy, control of differentiation/undifferentiation of cell and antibody therapy 有权建立包含酸性氨基酸，能够稳定细胞中蛋白质，适用于蛋白质治疗，控制细胞分化/未分化和抗体治疗的基序公开(公告)号：US09079968B2
公开(公告)日：2015-07-14
申请号：US13321381
申请日：2009-11-20
IPC分类号： C07K14/47
CPC分类号： C07K14/4703 , C07K14/4702 , C07K14/4705
摘要： A motif is searched which can inhibit the proteolysis of a protein that has been administered to a cell or an individual. Thus, disclosed is a method for designing/producing a protein having resistance to proteolysis. Specifically disclosed is a motif capable of inhibiting proteolysis, which comprises an amino acid region lying between the 396th position and the 410th position from the C-terminal of DP-1.
摘要翻译： 搜索可抑制已经施用于细胞或个体的蛋白质的蛋白水解的图案。 因此，公开了设计/制造具有蛋白水解抗性的蛋白质的方法。 具体公开的是能够抑制蛋白水解的基序，其包含位于DP-1的C-末端的第396位和410位之间的氨基酸区。
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2.发明申请公开(公告)号：US20130288948A1
公开(公告)日：2013-10-31
申请号：US13321381
申请日：2009-11-20
IPC分类号： C07K14/47
CPC分类号： C07K14/4703 , C07K14/4702 , C07K14/4705
摘要： A motif is searched which can inhibit the proteolysis of a protein that has been administered to a cell or an individual. Thus, disclosed is a method for designing/producing a protein having resistance to proteolysis. Specifically disclosed is a motif capable of inhibiting proteolysis, which comprises an amino acid region lying between the 396th position and the 410th position from the C-terminal of DP-1.
摘要翻译： 搜索可抑制已经施用于细胞或个体的蛋白质的蛋白水解的图案。 因此，公开了设计/制造具有蛋白水解抗性的蛋白质的方法。 具体公开的是能够抑制蛋白水解的基序，其包含位于DP-1的C-末端的第396位和410位之间的氨基酸区。
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