公开(公告)号：US5820877A

公开(公告)日：1998-10-13

申请号：US663186

申请日：1996-06-14

申请人： Hisashi Yamaguchi ,  Hiroyuki Maeda ,  Yoshirou Kamihoriuchi

发明人： Hisashi Yamaguchi ,  Hiroyuki Maeda ,  Yoshirou Kamihoriuchi

IPC分类号： A61M35/00 ,  A61K9/70 ,  A61L15/16 ,  A61M37/00

CPC分类号： A61K9/703 ,  A61K9/7084

摘要： A percutaneous or permucosal patch drug preparation. The preparation includes: (1) a backing layer impermeable to a drug component, (2) a drug storage layer which holds the drug component therein and is situated under the central portion of the backing layer, (3) a protective film which is impermeable to the drug component, has notches and is situated under the drug storage layer and the peripheral portion of the backing layer, (4) a pressure-sensitive adhesive layer which is situated under the protective film, and (5) a releasable liner layer which is impermeable to the drug component and situated under the pressure-sensitive layer. When the releasable liner layer is peeled off of the preparation, the protective film is torn along the notches and the portion of the protective film surrounded by the notches is removed together with the releasable liner layer and a portion of the adhesive between the protective film and the releasable liner layer. The patch drug preparation is held on the skin or mucosa of a patient by the pressure-sensitive adhesive remaining on the peripheral portion of the protective film. The drug held in the drug storage layer is released directly to the mucosa or to the skin.

摘要翻译： PCT No.PCT / AU95 / 00124 Sec。 371日期1996年6月14日第 102（e）日期1996年6月14日PCT 1995年3月10日PCT PCT。 第WO95 / 16440号公报 日期：1995年6月22日经皮或粘膜贴剂药物制剂。 该制剂包括：（1）药物成分不可渗透的背层，（2）将药物成分保持在其中并位于背衬层中心部分下方的药物储存层，（3）不渗透保护膜 具有切口并且位于药物储存层和背衬层的周边部分之下，（4）位于保护膜下方的压敏粘合剂层，和（5）可剥离衬垫层， 对药物成分是不可渗透的，位于压敏层下方。 当可释放的衬里层从制剂上剥离时，保护膜沿着切口撕开，并且由凹口包围的保护膜的部分与可剥离的衬垫层一起被去除，一部分粘合剂在保护膜和 可剥离衬里层。 贴剂药物制剂通过保留在保护膜周边部分上的压敏粘合剂保持在患者的皮肤或粘膜上。 保存在药物储存层中的药物直接释放到粘膜或皮肤上。