公开(公告)号：US06518045B1

公开(公告)日：2003-02-11

申请号：US09302495

申请日：1999-04-30

申请人： Takayuki Imamura ,  Hiroaki Maeda ,  Takeshi Fujiyasu ,  Yoshitaka Imagawa ,  Sachio Tokiyoshi

发明人： Takayuki Imamura ,  Hiroaki Maeda ,  Takeshi Fujiyasu ,  Yoshitaka Imagawa ,  Sachio Tokiyoshi

IPC分类号： C12P2104

CPC分类号： C07K14/52 ,  A61K38/00

摘要： A novel feline cytokine protein having the activity to enhance the cytotoxic activity of feline cytotoxic T lymphocytes, a DNA sequence coding for said protein, a recombinant DNA for expressing said protein, an expression vector comprising said recombinant DNA, a transformant which is transformed with said expression vector, a process for preparing said protein by culturing said transformant, and an antibody against said protein are provided. The novel feline cytokine protein of the present invention is a heterologous dimer comprising FLAF p35 and FLAF p40 and can be used for treating feline infectious diseases such as feline herpes virus type 1 (FHV-1) or feline calicivirus (FCV).

公开(公告)号：US06566097B2

公开(公告)日：2003-05-20

申请号：US10079616

申请日：2002-02-22

申请人： Takayuki Imamura ,  Hiroaki Maeda ,  Takeshi Fujiyasu ,  Yoshitaka Imagawa ,  Sachio Tokiyoshi

发明人： Takayuki Imamura ,  Hiroaki Maeda ,  Takeshi Fujiyasu ,  Yoshitaka Imagawa ,  Sachio Tokiyoshi

IPC分类号： C12P2106

CPC分类号： C07K14/52 ,  A61K38/00

摘要： A novel feline cytokine protein having the activity to enhance the cytotoxic activity of feline cytotoxic T lymphocytes, a DNA sequence coding for said protein, a recombinant DNA for expressing said protein, an expression vector comprising said recombinant DNA, a transformant which is transformed with said expression vector, a process for preparing said protein by culturing said transformant, and an antibody against said protein are provided. The novel feline cytokine protein of the present invention is a heterologous dimer comprising FLAF p35 and FLAF p40 and can be used for treating feline infectious diseases such as feline herpes virus type 1 (FHV-1) or feline calicivirus (FCV).

公开(公告)号：US06472509B1

公开(公告)日：2002-10-29

申请号：US09011143

申请日：1998-02-04

申请人： Takayuki Imamura ,  Hiroaki Maeda ,  Takeshi Fujiyasu ,  Yoshitaka Imagawa ,  Sachio Tokiyoshi

发明人： Takayuki Imamura ,  Hiroaki Maeda ,  Takeshi Fujiyasu ,  Yoshitaka Imagawa ,  Sachio Tokiyoshi

IPC分类号： C07K1400

CPC分类号： C07K14/52 ,  A61K38/00

摘要： A novel feline cytokine protein having the activity to enhance the cytotoxic activity of feline cytotoxic T lymphocytes, a DNA sequence coding for said protein, a recombinant DNA for expressing said protein, an expression vector comprising said recombinant DNA, a transformant which is transformed with said expression vector, a process for preparing said protein by culturing said transformant, and an antibody against said protein are provided. The novel feline cytokine protein of the present invention is a heterologous dimer comprising FLAF p35 and FLAF p40 and can be used for treating feline infectious diseases such as feline herpes virus type 1 (FHV-1) or feline calicivirus (FCV).

摘要翻译： 一种具有增强猫细胞毒性T淋巴细胞的细胞毒性活性，编码所述蛋白质的DNA序列，表达所述蛋白质的重组DNA，包含所述重组DNA的表达载体的活性的新型猫科动物细胞因子蛋白， 表达载体，通过培养所述转化体制备所述蛋白质的方法和针对所述蛋白质的抗体。 本发明的新型猫科动物细胞因子蛋白是包含FLAF p35和FLAF p40的异源二聚体，可用于治疗猫感染性疾病如1型（FHV-1）或猫杯状病毒（FCV）。