公开(公告)号：US20070213358A1

公开(公告)日：2007-09-13

申请号：US11574398

申请日：2005-09-03

申请人： Jae-Gyu Kim ,  Byung-Nak Ahn ,  Hyouk-Woo Lee ,  Suk-Won Yoon ,  Young-Ae Yoon ,  Choong-Hyun Lee ,  Myung-Hun Cha ,  Heui-Il Kang ,  Sun-Young Jang

发明人： Jae-Gyu Kim ,  Byung-Nak Ahn ,  Hyouk-Woo Lee ,  Suk-Won Yoon ,  Young-Ae Yoon ,  Choong-Hyun Lee ,  Myung-Hun Cha ,  Heui-Il Kang ,  Sun-Young Jang

IPC分类号： A61K31/4745 ,  C07D471/02

CPC分类号： C07D471/04

摘要： The present invention provides novel pyrrolo[3,2-b]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[3,2-b]pyridine derivatives or pharmaceutically acceptable salts thereof of the present invention have excellent proton pump inhibition effects and possess the ability to attain a reversible proton pump inhibitory effect.

摘要翻译： 本发明提供了新颖的吡咯并[3,2-b]吡啶衍生物或其药学上可接受的盐，其制备方法和包含其的组合物。 本发明的吡咯并[3,2-b]吡啶衍生物或其药学上可接受的盐具有优异的质子泵抑制作用，具有获得可逆质子泵抑制作用的能力。

公开(公告)号：US09890138B2

公开(公告)日：2018-02-13

申请号：US14001489

申请日：2012-02-24

申请人： Hyun-Joo Lee ,  Dong-Hoon Kim ,  Tae-Kyun Kim ,  Young-Ae Yoon ,  Jae-Young Sim ,  Myung-Hun Cha ,  Eun-Jung Jung ,  Kyoung-Kyu Ahn ,  Tai-Au Lee

发明人： Hyun-Joo Lee ,  Dong-Hoon Kim ,  Tae-Kyun Kim ,  Young-Ae Yoon ,  Jae-Young Sim ,  Myung-Hun Cha ,  Eun-Jung Jung ,  Kyoung-Kyu Ahn ,  Tai-Au Lee

IPC分类号： C07D403/04 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04

CPC分类号： C07D403/04 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04

摘要： The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.

公开(公告)号：US20150274700A2

公开(公告)日：2015-10-01

申请号：US14001489

申请日：2012-02-24

申请人： Hyun-Joo LEE ,  Dong-Hoon KIM ,  Tae-Kyun KIM ,  Young-Ae YOON ,  Jae-Young SIM ,  Myung-Hun CHA ,  Eun-Jung JUNG ,  Kyoung-Kyu AHN ,  Tai-Au LEE

发明人： Hyun-Joo LEE ,  Dong-Hoon KIM ,  Tae-Kyun KIM ,  Young-Ae YOON ,  Jae-Young SIM ,  Myung-Hun CHA ,  Eun-Jung JUNG ,  Kyoung-Kyu AHN ,  Tai-Au LEE

IPC分类号： C07D403/04

CPC分类号： C07D403/04 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04

摘要： The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.

摘要翻译： 本发明提供二氨基嘧啶衍生物或其药学上可接受的盐，其制备方法，包含该二胺化合物的药物组合物及其用途。 二氨基嘧啶衍生物或其药学上可接受的盐用作5-HT 4受体激动剂，因此可用于预防或治疗胃肠道运动功能障碍，胃肠道疾病之一，例如胃食管反流病（GERD），便秘，易怒 肠综合征（IBS），消化不良，术后肠梗阻，胃排空迟缓，胃轻瘫，肠假性梗阻，药物诱导的延迟转移或糖尿病胃失调。

公开(公告)号：US08513277B2

公开(公告)日：2013-08-20

申请号：US13296378

申请日：2011-11-15

申请人： Jae-Gyu Kim ,  Byung-Nak Ahn ,  Hyouk-Woo Lee ,  Suk-Won Yoon ,  Young-Ae Yoon ,  Dong-Hoon Kim ,  Se-Hoon Keum ,  Young-Ah Shin ,  Heui Il Kang ,  Sun-Young Jang

发明人： Jae-Gyu Kim ,  Byung-Nak Ahn ,  Hyouk-Woo Lee ,  Suk-Won Yoon ,  Young-Ae Yoon ,  Dong-Hoon Kim ,  Se-Hoon Keum ,  Young-Ah Shin ,  Heui Il Kang ,  Ryong Choi

IPC分类号： A61K31/4709 ,  A61P29/00 ,  A61P1/04 ,  A61P1/00 ,  C07D471/04

CPC分类号： C07D471/04

摘要： The present invention provides novel pyrrolo[3,2-c]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[3,2-c]pyridine derivatives or pharmaceutically acceptable salts thereof of the present invention have excellent proton pump inhibition effects and possess the ability to attain a reversible proton pump inhibitory effect.

摘要翻译： 本发明提供新颖的吡咯并[3,2-c]吡啶衍生物或其药学上可接受的盐，其制备方法和包含其的组合物。 本发明的吡咯并[3,2-c]吡啶衍生物或其药学上可接受的盐具有优异的质子泵抑制作用，具有获得可逆质子泵抑制效果的能力。

公开(公告)号：US07642269B2

公开(公告)日：2010-01-05

申请号：US11574398

申请日：2005-09-03

申请人： Jae-Gyu Kim ,  Byung-Nak Ahn ,  Hyouk-Woo Lee ,  Suk-Won Yoon ,  Young-Ae Yoon ,  Choong-Hyun Lee ,  Myung-Hun Cha ,  Heui-Il Kang ,  Sun-Young Jang

发明人： Jae-Gyu Kim ,  Byung-Nak Ahn ,  Hyouk-Woo Lee ,  Suk-Won Yoon ,  Young-Ae Yoon ,  Choong-Hyun Lee ,  Myung-Hun Cha ,  Heui-Il Kang ,  Sun-Young Jang

IPC分类号： A61K31/4745 ,  C07D471/02

CPC分类号： C07D471/04

摘要： The present invention provides novel pyrrolo[3,2-b]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[3,2-b]pyridine derivatives or pharmaceutically acceptable salts thereof of the present invention have excellent proton pump inhibition effects and possess the ability to attain a reversible proton pump inhibitory effect.

摘要翻译： 本发明提供了新颖的吡咯并[3,2-b]吡啶衍生物或其药学上可接受的盐，其制备方法和包含其的组合物。 本发明的吡咯并[3,2-b]吡啶衍生物或其药学上可接受的盐具有优异的质子泵抑制作用，具有获得可逆质子泵抑制作用的能力。

公开(公告)号：US07541366B2

公开(公告)日：2009-06-02

申请号：US11574406

申请日：2005-09-03

申请人： Jae-Gyu Kim ,  Byung-Nak Ahn ,  Hyouk-Woo Lee ,  Suk-Won Yoon ,  Young-Ae Yoon ,  Hyun-Ho Choi ,  Heui-Il Kang

发明人： Jae-Gyu Kim ,  Byung-Nak Ahn ,  Hyouk-Woo Lee ,  Suk-Won Yoon ,  Young-Ae Yoon ,  Hyun-Ho Choi ,  Heui-Il Kang

IPC分类号： A61K31/437 ,  C07D471/04

CPC分类号： C07D471/04

摘要： The present invention provides novel pyrrolo[3,2-c]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[3,2-c]pyridine derivatives or pharmaceutically acceptable salts thereof of the present invention have excellent proton pump inhibition effects and possess the ability to attain a reversible proton pump inhibitory effect.

摘要翻译： 本发明提供新颖的吡咯并[3,2-c]吡啶衍生物或其药学上可接受的盐，其制备方法和包含其的组合物。 本发明的吡咯并[3,2-c]吡啶衍生物或其药学上可接受的盐具有优异的质子泵抑制作用，具有获得可逆质子泵抑制效果的能力。

公开(公告)号：US20090005409A1

公开(公告)日：2009-01-01

申请号：US11574393

申请日：2005-09-03

申请人： Jae-Gyu Kim ,  Byung-Nak Ahn ,  Hyouk-Woo Lee ,  Suk-Won Yoon ,  Young-Ae Yoon ,  Dong-Hoon Kim ,  Se-Hoon Keum ,  Young-Ah Shin ,  Heui Il Kang ,  Ryong Choi ,  Sun-Young Jang

发明人： Jae-Gyu Kim ,  Byung-Nak Ahn ,  Hyouk-Woo Lee ,  Suk-Won Yoon ,  Young-Ae Yoon ,  Dong-Hoon Kim ,  Se-Hoon Keum ,  Young-Ah Shin ,  Heui Il Kang ,  Ryong Choi ,  Sun-Young Jang

IPC分类号： A61K31/437 ,  C07D471/04

CPC分类号： C07D471/04

摘要： The present invention provides novel pyrrolo[3,2-c]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[3,2-c]pyridine derivatives or pharmaceutically acceptable salts thereof of the present invention have excellent proton pump inhibition effects and possess the ability to attain a reversible proton pump inhibitory effect.

摘要翻译： 本发明提供新颖的吡咯并[3,2-c]吡啶衍生物或其药学上可接受的盐，其制备方法和包含其的组合物。 本发明的吡咯并[3,2-c]吡啶衍生物或其药学上可接受的盐具有优异的质子泵抑制作用，具有获得可逆质子泵抑制效果的能力。

公开(公告)号：US20130338179A1

公开(公告)日：2013-12-19

申请号：US14001489

申请日：2012-02-24

申请人： Hyun-Joo Lee ,  Dong-Hoon Kim ,  Tae-Kyun Kim ,  Young-Ae Yoon ,  Jae-Young Sim ,  Myung-Hun Cha ,  Eun-Jung Jung ,  Kyoung-Kyu Ahn ,  Tai-Au Lee

发明人： Hyun-Joo Lee ,  Dong-Hoon Kim ,  Tae-Kyun Kim ,  Young-Ae Yoon ,  Jae-Young Sim ,  Myung-Hun Cha ,  Eun-Jung Jung ,  Kyoung-Kyu Ahn ,  Tai-Au Lee

IPC分类号： C07D403/04

CPC分类号： C07D403/04 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04

摘要： The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.

公开(公告)号：US08188114B2

公开(公告)日：2012-05-29

申请号：US12613763

申请日：2009-11-06

申请人： Jae-Gyu Kim ,  Byung-Nak Ahn ,  Hyouk-Woo Lee ,  Suk-Won Yoon ,  Young-Ae Yoon ,  Dong-Hoon Kim ,  Chan-Sun Park ,  Seok-Hee Han ,  Myung-Hun Cha ,  Heui II Kang ,  Sun-Young Jang

发明人： Jae-Gyu Kim ,  Byung-Nak Ahn ,  Hyouk-Woo Lee ,  Suk-Won Yoon ,  Young-Ae Yoon ,  Dong-Hoon Kim ,  Chan-Sun Park ,  Seok-Hee Han ,  Myung-Hun Cha ,  Heui II Kang ,  Sun-Young Jang

IPC分类号： A61K31/437 ,  C07D471/04 ,  A61P1/04

CPC分类号： C07D471/04

摘要： The present invention provides novel pyrrolo[2,3-c]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[2,3-c]pyridine derivatives or pharmaceutically acceptable salts thereof of the present invention have excellent proton pump inhibition effects and possess the ability to attain a reversible proton pump inhibitory effect.

摘要翻译： 本发明提供新的吡咯并[2,3-c]吡啶衍生物或其药学上可接受的盐，其制备方法和包含其的组合物。 本发明的吡咯并[2,3-c]吡啶衍生物或其药学上可接受的盐具有优异的质子泵抑制作用，具有获得可逆质子泵抑制作用的能力。

公开(公告)号：US08148529B2

公开(公告)日：2012-04-03

申请号：US11574393

申请日：2005-09-03

申请人： Jae-Gyu Kim ,  Byung-Nak Ahn ,  Hyouk-Woo Lee ,  Suk-Won Yoon ,  Young-Ae Yoon ,  Dong-Hoon Kim ,  Se-Hoon Keum ,  Young-Ah Shin ,  Heui Il Kang ,  Ryong Choi ,  Sun-Young Jang, legal representative

发明人： Jae-Gyu Kim ,  Byung-Nak Ahn ,  Hyouk-Woo Lee ,  Suk-Won Yoon ,  Young-Ae Yoon ,  Dong-Hoon Kim ,  Se-Hoon Keum ,  Young-Ah Shin ,  Heui Il Kang ,  Ryong Choi

IPC分类号： C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C07D513/02

CPC分类号： C07D471/04

摘要： The present invention provides novel pyrrolo[3,2-c]pyridine derivatives or pharmaceutically acceptable salts thereof, processes for the preparation thereof, and compositions comprising the same. The pyrrolo[3,2-c]pyridine derivatives or pharmaceutically acceptable salts thereof of the present invention have excellent proton pump inhibition effects and possess the ability to attain a reversible proton pump inhibitory effect.

摘要翻译： 本发明提供新颖的吡咯并[3,2-c]吡啶衍生物或其药学上可接受的盐，其制备方法和包含其的组合物。 本发明的吡咯并[3,2-c]吡啶衍生物或其药学上可接受的盐具有优异的质子泵抑制作用，具有获得可逆质子泵抑制效果的能力。