公开(公告)号：US20060018961A1

公开(公告)日：2006-01-26

申请号：US11236640

申请日：2005-09-28

申请人： Naoko Nakamura ,  Naoki Kameyama ,  Akihito Iwasa ,  Yukinari Iwata

发明人： Naoko Nakamura ,  Naoki Kameyama ,  Akihito Iwasa ,  Yukinari Iwata

IPC分类号： A61K9/20 ,  A61K31/366

CPC分类号： A61K9/2018 ,  A61K9/0056 ,  A61K9/2013 ,  A61K9/2027 ,  A61K31/366 ,  A61K45/06 ,  A61K2300/00

摘要： A compression formed preparation that rapidly disintegrates in the mouth or in an aqueous solvent, which imparts an excellent feeling during administration, and maintains a suitable hardness required for handling such as distribution and the like, and a method for manufacturing the compression formed preparation. The present invention provides a rapidly disintegrating compression formed preparation comprising one or more compounds selected from gluconolactones and pullulans added to the pharmaceutical base. The pharmaceutical base is preferably a saccharide and particularly preferably a sugar alcohol and starch syrup. The compression formed preparation is prepared by compressing granules obtained by granulation of particles comprising preparation assistants in addition to the pharmaceutical base in a solution of gluconolactone or pullulan dissolved in an aqueous solvent or together with gluconolactone or pullulan in an aqueous solvent.

摘要翻译： 一种在口腔或水性溶剂中快速崩解的压制成型制剂，其在给药期间赋予优异的感觉，并保持诸如分布等的处理所需的合适的硬度，以及压缩成型制剂的制造方法。 本发明提供了包含一种或多种选自加入到药物基质中的葡糖酸内酯和支链淀粉的化合物的快速崩解的压制成形制剂。 药物基质优选为糖类，特别优选糖醇和淀粉糖浆。 通过将溶解在水性溶剂中的葡萄糖酸内酯或支链淀粉的溶液中的制剂助剂以外的制剂助剂颗粒压制成颗粒而得到的压缩成型制剂，或者与葡萄糖酸内酯或支链淀粉一起在水性溶剂中。