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公开(公告)号:US4649199A
公开(公告)日:1987-03-10
申请号:US697918
申请日:1985-02-04
IPC分类号: C07D498/22 , C12P17/18 , C12R1/465 , A61K31/495
CPC分类号: C07D498/22
摘要: A pharmacologically acceptable acid addition salt of DC-52 with 0.5-2.0 equivalent weight of inorganic acid, sulfonic acid, acidic amino acid, citric acid, transaconitic acid, .alpha.-ketoglutaric acid, itaconic acid, malonic acid or ascorbic acid on the basis of DC-52, having the same degree of antitumor activity as DC-52, is superior to DC-52 in stability at powdering or at preservation.
摘要翻译: 磺酸,酸性氨基酸,柠檬酸,经官能度酸,α-酮戊二酸,衣康酸,丙二酸或抗坏血酸的基础上,加入0.5〜2.0当量的DC-52的药理学上可接受的酸加成盐 与DC-52具有相同程度的抗肿瘤活性的DC-52在粉化或保存时的稳定性优于DC-52。