公开(公告)号：US09095643B2

公开(公告)日：2015-08-04

申请号：US13129765

申请日：2009-09-17

申请人： Jin-suk Choi ,  Young-woo Lee ,  Yun-gee Lee ,  Jun-ho Kim ,  Jin-ho Lee

发明人： Jin-suk Choi ,  Young-woo Lee ,  Yun-gee Lee ,  Jun-ho Kim ,  Jin-ho Lee

IPC分类号： A61L31/14 ,  A61L31/04

CPC分类号： A61L31/14 ,  A61L31/041 ,  C08L71/02

摘要： Provided is a composition preventing tissue adhesion and a method for preparing the same, and, more particularly, a composition preventing tissue adhesion which further contains a drug selectively inhibiting inflammatory response and a method for preparing the composition, in which the composition is produced through a chemical reaction by adding a cross-linking agent to an aqueous solution which contains a block copolymer containing a polyethyleneoxide block having the ability to suppress tissue adhesion, and a polymer with 10,000 to 1,000,000 g/mol of molecular weight which can be mixed with the copolymer; the composition is characterized in that the difference of viscosity, absorbance of visible rays region, and stability between the upper and lower liquid layers are within 10% when centrifuging the composition; and also the method for preparing the composition enhances cross-linking homogenization and viscosity stability through simultaneous spraying and stirring methods without a reaction retardant.

摘要翻译： 本发明提供了防止组织粘连的组合物及其制备方法，更具体地，涉及进一步含有选择性抑制炎症反应的药物的组织粘连的组合物及其制备方法，其中通过 通过向包含具有抑制组织粘附能力的聚环氧乙烷嵌段的嵌段共聚物的水溶液中加入交联剂进行化学反应，和可与共聚物混合的分子量为10,000〜1,000,000g / mol的聚合物 ; 该组合物的特征在于，离心组合物时，粘度差，可见光区域的吸光度和上，下液层之间的稳定性在10％以内; 并且制备该组合物的方法通过不具有反应阻滞剂的同时喷雾和搅拌方法增强交联均化和粘度稳定性。

公开(公告)号：US20110229432A1

公开(公告)日：2011-09-22

申请号：US13129765

申请日：2009-09-17

申请人： Jin-suk Choi ,  Young-woo Lee ,  Yun-gee Lee ,  Jun-ho Kim ,  Jin-ho Lee

发明人： Jin-suk Choi ,  Young-woo Lee ,  Yun-gee Lee ,  Jun-ho Kim ,  Jin-ho Lee

IPC分类号： A61K31/765 ,  A61P43/00

CPC分类号： A61L31/14 ,  A61L31/041 ,  C08L71/02

摘要： Provided is a thermosensitive composition preventing tissue adhesion and a method for preparing the same, and, more particularly, a thermosensitive composition preventing tissue adhesion which further contains a drug selectively inhibiting inflammatory response and a method for preparing the composition, in which the composition is produced through a chemical reaction by adding a cross-linking agent to an aqueous solution which contains a block copolymer containing a polyethyleneoxide block having the ability to suppress tissue adhesion, and a polymer with 10,000 to 1,000,000 g/mol of molecular weight which can be mixed with the copolymer; the composition is characterized in that the difference of viscosity, absorbance of visible rays region, and stability between the upper and lower liquid layers are within 10% when centrifuging the composition; and also the method for preparing the composition enhances cross-linking homogenization and viscosity stability through simultaneous spraying and stirring methods without a reaction retardant.

摘要翻译： 提供了防止组织粘连的热敏组合物及其制备方法，更具体地，涉及进一步含有选择性抑制炎性反应的药物的组织粘连的热敏组合物及其制备方法，其中制备组合物 通过在包含含有具有抑制组织粘附能力的聚环氧乙烷嵌段的嵌段共聚物的水溶液中加入交联剂的化学反应，以及可以与10,000〜1000,000g / mol的分子量混合的聚合物 共聚物; 该组合物的特征在于，离心组合物时，粘度差，可见光区域的吸光度和上，下液层之间的稳定性在10％以内; 并且制备该组合物的方法通过不具有反应阻滞剂的同时喷雾和搅拌方法增强交联均化和粘度稳定性。