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    METHODS, COMPOSITIONS, AND KITS RELATING TO CHITINASES AND CHITINASE-LIKE MOLECULES AND INFLAMMATORY DISEASE
    1.
    发明申请
    METHODS, COMPOSITIONS, AND KITS RELATING TO CHITINASES AND CHITINASE-LIKE MOLECULES AND INFLAMMATORY DISEASE 审中-公开
    方法，组合物和与基因和类似分子和炎症疾病有关的组合物

    公开(公告)号：US20090162347A1

    公开(公告)日：2009-06-25

    申请号：US12275737

    申请日：2008-11-21

    申请人： Jack A. Elias ,  Zhou Zhu

    发明人： Jack A. Elias ,  Zhou Zhu

    IPC分类号： A61K39/395 ,  A61P11/06

    CPC分类号： A61K39/395 ,  A61K31/00 ,  A61K31/70 ,  A61K38/12 ,  C07K16/18 ,  C07K16/40 ,  C07K2317/77 ,  C12N9/2442 ,  C12Y302/01014 ,  Y10S424/81 ,  Y10S530/868

    摘要： The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic rhinitis, scleroderma, and the like), relating to inhibiting a chitinase-like molecule. The invention further includes methods to identify new compounds for the treatment of inflammatory disease, including, but not limited to, asthma, COPD and the like. This is because the present invention demonstrates, for the first time, that expression of IL-13, and of a chitinase-like molecule, mediates and/or is associated with inflammatory disease and that inhibiting the chitinase-like molecule treats and even prevents, the disease. Thus, the invention relates to the novel discovery that inhibiting a chitinase-like molecule treats and prevents an inflammatory disease.

    摘要翻译： 本发明包括与抑制几丁质酶样分子有关的炎性疾病（例如哮喘，COPD，炎性肠病，特应性皮炎，特应性，过敏，过敏性鼻炎，硬皮病等）的组合物和方法。 本发明还包括鉴定用于治疗炎症性疾病的新化合物的方法，包括但不限于哮喘，COPD等。 这是因为本发明首次证明IL-13和几丁质酶样分子的表达介导和/或与炎性疾病相关，并且抑制几丁质酶样分子治疗甚至预防， 这种病。 因此，本发明涉及抑制几丁质酶样分子治疗和预防炎性疾病的新发现。

    Methods, compositions and kits relating to chitnases and chitnase-like molecules and inflammation disease
    3.
    发明授权
    Methods, compositions and kits relating to chitnases and chitnase-like molecules and inflammation disease 有权
    方法，组合物和试剂盒涉及chitnases和chitnase样分子和炎症疾病

    公开(公告)号：US08679503B2

    公开(公告)日：2014-03-25

    申请号：US12834650

    申请日：2010-07-12

    申请人： Jack A. Elias ,  Zhou Zhu

    发明人： Jack A. Elias ,  Zhou Zhu

    IPC分类号： A61K39/395 ,  C07K16/40

    CPC分类号： A61K39/395 ,  A61K31/00 ,  A61K31/70 ,  A61K38/12 ,  C07K16/18 ,  C07K16/40 ,  C07K2317/77 ,  C12N9/2442 ,  C12Y302/01014 ,  Y10S424/81 ,  Y10S530/868

    摘要： The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic rhinitis, scleroderma, and the like), relating to inhibiting a chitinase-like molecule. The invention further includes methods to identify new compounds for the treatment of inflammatory disease, including, but not limited to, asthma, COPD and the like. This is because the present invention demonstrates, for the first time, that expression of IL-13, and of a chitinase-like molecule, mediates and/or is associated with inflammatory disease and that inhibiting the chitinase-like molecule treats and even prevents, the disease. Thus, the invention relates to the novel discovery that inhibiting a chitinase-like molecule treats and prevents an inflammatory disease.

    摘要翻译： 本发明包括与抑制几丁质酶样分子有关的炎性疾病（例如哮喘，COPD，炎性肠病，特应性皮炎，特应性，过敏，过敏性鼻炎，硬皮病等）的组合物和方法。 本发明还包括鉴定用于治疗炎症性疾病的新化合物的方法，包括但不限于哮喘，COPD等。 这是因为本发明首次证明IL-13和几丁质酶样分子的表达介导和/或与炎性疾病相关，并且抑制几丁质酶样分子治疗甚至预防， 这种病。 因此，本发明涉及抑制几丁质酶样分子治疗和预防炎性疾病的新发现。

    Methods, compositions and kits relating to chitinases and chitinase-like molecules and inflammatory disease
    4.
    发明授权
    Methods, compositions and kits relating to chitinases and chitinase-like molecules and inflammatory disease 有权
    与几丁质酶和几丁质酶样分子和炎性疾病有关的方法，组合物和试剂盒

    公开(公告)号：US07214373B2

    公开(公告)日：2007-05-08

    申请号：US10202436

    申请日：2002-07-23

    申请人： Jack A. Elias ,  Zhou Zhu

    发明人： Jack A. Elias ,  Zhou Zhu

    IPC分类号： A61K39/395

    CPC分类号： A61K39/395 ,  A61K31/00 ,  A61K31/70 ,  A61K38/12 ,  C07K16/18 ,  C07K16/40 ,  C07K2317/77 ,  C12N9/2442 ,  C12Y302/01014 ,  Y10S424/81 ,  Y10S530/868

    摘要： The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic rhinitis, scleroderma, and the like), relating to inhibiting a chitinase-like molecule. The invention further includes methods to identify new compounds for the treatment of inflammatory disease, including, but not limited to, asthma, COPD and the like. This is because the present invention demonstrates, for the first time, that expression of IL-13, and of a chitinase-like molecule, mediates and/or is associated with inflammatory disease and that inhibiting the chitinase-like molecule treats and even prevents, the disease. Thus, the invention relates to the novel discovery that inhibiting a chitinase-like molecule treats and prevents an inflammatory disease.

    摘要翻译： 本发明包括与抑制几丁质酶样分子有关的炎性疾病（例如哮喘，COPD，炎性肠病，特应性皮炎，特应性，过敏，过敏性鼻炎，硬皮病等）的组合物和方法。 本发明还包括鉴定用于治疗炎症性疾病的新化合物的方法，包括但不限于哮喘，COPD等。 这是因为本发明首次证明IL-13和几丁质酶样分子的表达介导和/或与炎性疾病相关，并且抑制几丁质酶样分子治疗甚至预防， 这种病。 因此，本发明涉及抑制几丁质酶样分子治疗和预防炎性疾病的新发现。

    Methods, Compositions and Kits Relating to Chitnases and Chitnase-Like Molecules and Inflammation Disease
    5.
    发明申请
    Methods, Compositions and Kits Relating to Chitnases and Chitnase-Like Molecules and Inflammation Disease 有权
    方法，组合物和试剂盒与Chitnases和Chitnase样分子和炎症疾病有关

    公开(公告)号：US20130136751A1

    公开(公告)日：2013-05-30

    申请号：US12834650

    申请日：2010-07-12

    申请人： Jack A. Elias ,  Zhou Zhu

    发明人： Jack A. Elias ,  Zhou Zhu

    IPC分类号： C07K16/18 ,  C07K16/40

    CPC分类号： A61K39/395 ,  A61K31/00 ,  A61K31/70 ,  A61K38/12 ,  C07K16/18 ,  C07K16/40 ,  C07K2317/77 ,  C12N9/2442 ,  C12Y302/01014 ,  Y10S424/81 ,  Y10S530/868

    摘要： The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic rhinitis, scleroderma, and the like), relating to inhibiting a chitinase-like molecule. The invention further includes methods to identify new compounds for the treatment of inflammatory disease, including, but not limited to, asthma, COPD and the like. This is because the present invention demonstrates, for the first time, that expression of IL-13, and of a chitinase-like molecule, mediates and/or is associated with inflammatory disease and that inhibiting the chitinase-like molecule treats and even prevents, the disease. Thus, the invention relates to the novel discovery that inhibiting a chitinase-like molecule treats and prevents an inflammatory disease.

    摘要翻译： 本发明包括与抑制几丁质酶样分子有关的炎性疾病（例如哮喘，COPD，炎性肠病，特应性皮炎，特应性，过敏，过敏性鼻炎，硬皮病等）的组合物和方法。 本发明还包括鉴定用于治疗炎症性疾病的新化合物的方法，包括但不限于哮喘，COPD等。 这是因为本发明首次证明IL-13和几丁质酶样分子的表达介导和/或与炎性疾病相关，并且抑制几丁质酶样分子治疗甚至预防， 这种病。 因此，本发明涉及抑制几丁质酶样分子治疗和预防炎性疾病的新发现。

    Methods, compositions, and kits relating to chitinases and chitinase-like molecules and inflammatory disease
    6.
    发明申请
    Methods, compositions, and kits relating to chitinases and chitinase-like molecules and inflammatory disease 审中-公开
    与几丁质酶和几丁质酶样分子和炎性疾病有关的方法，组合物和试剂盒

    公开(公告)号：US20090148539A1

    公开(公告)日：2009-06-11

    申请号：US12218840

    申请日：2008-07-18

    申请人： Jack A. Elias ,  Zhou Zhu

    发明人： Jack A. Elias ,  Zhou Zhu

    IPC分类号： A61K33/34 ,  A61K31/7042 ,  A61K31/4353 ,  A61K33/30 ,  A61P29/00 ,  A61K33/28 ,  A61K38/12 ,  A61K31/525

    CPC分类号： A61K39/395 ,  A61K31/00 ,  A61K31/70 ,  A61K38/12 ,  C07K16/18 ,  C07K16/40 ,  C07K2317/77 ,  C12N9/2442 ,  C12Y302/01014 ,  Y10S424/81 ,  Y10S530/868

    摘要： The present invention includes compositions and methods for the treatment of inflammatory disease (e.g. asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic rhinitis, scleroderma, and the like), relating to inhibiting a chitinase-like molecule. The invention further includes methods to identify new compounds for the treatment of inflammatory disease, including, but not limited to, asthma, COPD and the like. This is because the present invention demonstrates, for the first time, that expression of IL-13, and of a chitinase-like molecule, mediates and/or is associated with inflammatory disease and that inhibiting the chitinase-like molecule treats and even prevents, the disease. Thus, the invention relates to the novel discovery that inhibiting a chitinase-like molecule treats and prevents an inflammatory disease.

    摘要翻译： 本发明包括与抑制几丁质酶样分子有关的炎性疾病（例如哮喘，COPD，炎症性肠病，特应性皮炎，特应性，过敏，过敏性鼻炎，硬皮病等）的组合物和方法。 本发明还包括鉴定用于治疗炎症性疾病的新化合物的方法，包括但不限于哮喘，COPD等。 这是因为本发明首次证明IL-13和几丁质酶样分子的表达介导和/或与炎性疾病相关，并且抑制几丁质酶样分子治疗甚至预防， 这种病。 因此，本发明涉及抑制几丁质酶样分子治疗和预防炎性疾病的新发现。