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公开(公告)号：US20190032137A1
公开(公告)日：2019-01-31
申请号：US16031218
申请日：2018-07-10
发明人： Allen D. Roses
IPC分类号： C12Q1/6883 , A61K31/4439
摘要： Provided herein are genetic variants associated with development of a condition of interest (e.g., Alzheimer's disease). Methods of treatment with an active agent (e.g., with a particular active agent and/or at an earlier age) is also provided, upon detecting a genetic variant described herein. In some embodiments, the genetic variant is a deletion/insertion polymorphism (DIP) of the TOMM40 gene.
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公开(公告)号：US11001893B2
公开(公告)日：2021-05-11
申请号：US16308315
申请日：2017-06-09
发明人： Allen D. Roses
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6883
摘要： Provided herein according to some embodiments is a method for detecting a short tandem repeat (STR) variant in the SOD1, TARDBP or C9orf72 gene region comprising measuring the length of the STR variant. In some embodiments, the method V includes obtaining a biological sample containing genomic DNA from a subject, optionally isolating the genomic DNA from the sample. Also provided is a method for determining a diagnosis or a prognosis for a neurodegenerative disease, including: measuring a length of a short tandem repeat (STR) variant in the SOD1, TARDBP or C9orf72 gene region, and determining the diagnosis or prognosis based upon the length. Further provided is a method of treatment for a neurodegenerative disease including: administering a therapeutic agent to a subject based upon a length of a short tandem repeat (STR) variant in the SOD1, TARDBP or C9orf72 gene region in the subject. Also provided is a kit for detecting a (STR) variant in the SOD1, TARDBP or C9orf72 gene region.
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公开(公告)号：US20150073025A1
公开(公告)日：2015-03-12
申请号：US14332867
申请日：2014-07-16
发明人： Allen D. Roses
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172
摘要： Provided herein is a method for identifying a genetic variant that is associated with development of a condition of interest (e.g., Alzheimer's disease), and genetic variants so identified. Methods of treatment with an active agent (e.g., with a particular active agent and/or at an earlier age) is also provided, upon detecting a genetic variant described herein. In some embodiments, the genetic variant is a deletion/insertion polymorphism (DIP) of the TOMM40 gene. Kits for determining if a subject is at increased risk of developing late onset Alzheimer's disease is also provided. Kits for determining if a subject is responsive to treatment for a condition of interest with an active agent are further provided.
摘要翻译： 本文提供了用于鉴定与兴趣条件（例如阿尔茨海默病）的发展相关的遗传变异体和如此鉴定的遗传变异体的方法。 在检测本文所述的遗传变体时，还提供了用活性剂（例如，与特定活性剂和/或较早年龄）一起治疗的方法。 在一些实施方案中，遗传变体是TOMM40基因的缺失/插入多态性（DIP）。 还提供了用于确定受试者是否处于发病晚期阿尔茨海默氏病的风险增加的试剂盒。 进一步提供用于确定受试者是否对活性成分感兴趣的病症的治疗有反应的试剂盒。
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公开(公告)号：US20150073022A1
公开(公告)日：2015-03-12
申请号：US14464961
申请日：2014-08-21
发明人： Allen D. Roses
IPC分类号： C12Q1/68 , A61K31/4439
CPC分类号： C12Q1/6883 , A61K31/4439 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156
摘要： Provided herein are genetic variants associated with development of a condition of interest (e.g., Alzheimer's disease). Methods of treatment with an active agent (e.g., with a particular active agent and/or at an earlier age) is also provided, upon detecting a genetic variant described herein. In some embodiments, the genetic variant is a deletion/insertion polymorphism (DIP) of the TOMM40 gene.
摘要翻译： 本文提供与感兴趣的疾病的发展相关的遗传变异（例如，阿尔茨海默病）。 在检测本文所述的遗传变体时，还提供了用活性剂（例如，与特定活性剂和/或较早年龄）一起治疗的方法。 在一些实施方案中，遗传变体是TOMM40基因的缺失/插入多态性（DIP）。
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公开(公告)号：US20210095345A1
公开(公告)日：2021-04-01
申请号：US17097705
申请日：2020-11-13
发明人： Allen D. Roses
IPC分类号： C12Q1/6883
摘要： Provided herein is a method for identifying a genetic variant that is associated with development of a condition of interest (e.g., Alzheimer's disease), and genetic variants so identified. Methods of treatment with an active agent (e.g., with a particular active agent and/or at an earlier age) is also provided, upon detecting a genetic variant described herein. In some embodiments, the genetic variant is a deletion/insertion polymorphism (DIP) of the TOMM40 gene. Kits for determining if a subject is at increased risk of developing late onset Alzheimer's disease is also provided. Kits for determining if a subject is responsive to treatment for a condition of interest with an active agent are further provided.
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公开(公告)号：US20190151298A1
公开(公告)日：2019-05-23
申请号：US16259134
申请日：2019-01-28
发明人： Allen D. Roses , Rajneesh Taneja
IPC分类号： A61K31/4439 , C07D417/12 , C12Q1/6883
摘要： Provided herein are drug products with low dose pioglitazone for use in the treatment (e.g., delay of onset) of cognitive impairment of the Alzheimer's type. Methods of manufacture thereof are also provided. Further provided are methods of treatment for Alzheimer's disease including administering a drug product with low dose pioglitazone. The methods may include determining whether the subject is at risk of developing Alzheimer's disease based upon the subject's age and TOMM40 523 genotype.
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公开(公告)号：US20170319565A1
公开(公告)日：2017-11-09
申请号：US15600833
申请日：2017-05-22
发明人： Allen D. Roses , Rajneesh Taneja
IPC分类号： A61K31/4439 , C12Q1/68 , C07D417/12
CPC分类号： A61K31/4439 , C07D417/12 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , Y10T436/143333
摘要： Provided herein are drug products with low dose pioglitazone for use in the treatment (e.g., delay of onset) of cognitive impairment of the Alzheimer's type. Methods of manufacture thereof are also provided. Further provided are methods of treatment for Alzheimer's disease including administering a drug product with low dose pioglitazone. The methods may include determining whether the subject is at risk of developing Alzheimer's disease based upon the subject's age and TOMM40 523 genotype.
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公开(公告)号：US11179375B2
公开(公告)日：2021-11-23
申请号：US16259134
申请日：2019-01-28
发明人： Allen D. Roses , Rajneesh Taneja
IPC分类号： C12Q1/6883 , A61K31/4439 , C07D417/12
摘要： Provided herein are drug products with low dose pioglitazone for use in the treatment (e.g., delay of onset) of cognitive impairment of the Alzheimer's type. Methods of manufacture thereof are also provided. Further provided are methods of treatment for Alzheimer's disease including administering a drug product with low dose pioglitazone. The methods may include determining whether the subject is at risk of developing Alzheimer's disease based upon the subject's age and TOMM40 523 genotype.
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公开(公告)号：US11021751B2
公开(公告)日：2021-06-01
申请号：US16031218
申请日：2018-07-10
发明人： Allen D. Roses
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6883 , A61K31/4439
摘要： Provided herein are genetic variants associated with development of a condition of interest (e.g., Alzheimer's disease). Methods of treatment with an active agent (e.g., with a particular active agent and/or at an earlier age) is also provided, upon detecting a genetic variant described herein. In some embodiments, the genetic variant is a deletion/insertion polymorphism (DIP) of the TOMM40 gene.
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公开(公告)号：US20180363060A1
公开(公告)日：2018-12-20
申请号：US16021261
申请日：2018-06-28
发明人： Allen D. Roses
IPC分类号： C12Q1/6883
摘要： Provided herein is a method for identifying a genetic variant that is associated with development of a condition of interest (e.g., Alzheimer's disease), and genetic variants so identified. Methods of treatment with an active agent (e.g., with a particular active agent and/or at an earlier age) is also provided, upon detecting a genetic variant described herein. In some embodiments, the genetic variant is a deletion/insertion polymorphism (DIP) of the TOMM40 gene. Kits for determining if a subject is at increased risk of developing late onset Alzheimer's disease is also provided. Kits for determining if a subject is responsive to treatment for a condition of interest with an active agent are further provided.
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