公开(公告)号：US5069910A

公开(公告)日：1991-12-03

申请号：US366437

申请日：1989-06-15

申请人： Mateja Kovacic ,  Jenny Milovac ,  Polona Cvelbar ,  Anton Stalc ,  Zvezdana Trost ,  Zdravko Kopitar ,  Bojan Kofler ,  Vida Nikolic ,  Marija Lampret ,  Marija Lippai

发明人： Mateja Kovacic ,  Jenny Milovac ,  Polona Cvelbar ,  Anton Stalc ,  Zvezdana Trost ,  Zdravko Kopitar ,  Bojan Kofler ,  Vida Nikolic ,  Marija Lampret ,  Marija Lippai

IPC分类号： A61K9/20 ,  A61K31/415 ,  A61P1/04

CPC分类号： A61K31/415 ,  A61K9/2004 ,  A61K9/2013 ,  A61K9/2031

摘要： There are described novel dispersible cimetidine tablets containing 30 to 90% by weight of one of the polymorphous modifications of cimetidine A, B or C, 5 to 55% by weight of one or more disintegrationg agents, 0.05 to 5.0% by weight of a surfactant, such as sodium lauryl sulphate together with other common adjuvants. The process for the manufacture of dispersible cimetidine tablets is effected on the basis of known methods by granulating the ingredients and by compressing the granulate to tablets. Dispersible tablets disintegrate when brought in contact with water at room temperature within less than 1 minute to yield a fine dispersion, which facilitates the oral application. Therefore such tablets are particularly suitable for certain groups of patients, especially for the aged and children. Dispersible tablets containing cimetidine excell by their improved rate of dissolution and good bioavailability.