公开(公告)号：US20130253040A1

公开(公告)日：2013-09-26

申请号：US13781176

申请日：2013-02-28

申请人： C/O SANGAMO BIOSCIENCES, INC.

发明人： Jeffrey C. Miller ,  Edward J. Rebar ,  H. Steve Zhang

IPC分类号： C07K14/47

CPC分类号： A61K38/1709 ,  C07K14/4703 ,  C07K2319/00 ,  C07K2319/70 ,  C07K2319/71 ,  C07K2319/81 ,  C12N15/907

摘要： Disclosed herein are methods and compositions for treating or preventing Huntington's Disease.

公开(公告)号：US20130145503A1

公开(公告)日：2013-06-06

申请号：US13766380

申请日：2013-02-13

申请人： c/o Dow AgroSciences LLC ,  c/o Sangamo BioSciences, Inc.

发明人： Manju Gupta ,  Asha M. Palta ,  Stephen Novak ,  Fyodor Urnov ,  Sunita Gopalan

IPC分类号： C12N15/82

CPC分类号： C12N15/8213 ,  C07K2319/00 ,  C07K2319/81 ,  C12N9/1092 ,  C12N15/8243 ,  C12N15/8274

摘要： The present disclosure relates to engineered zinc finger proteins that target 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS) genes in plants and methods of using such zinc finger proteins in modulating gene expression, gene inactivation, and targeted gene modification. In particular, the disclosure pertains to zinc finger nucleases for targeted cleavage and alteration of EPSPS genes.

公开(公告)号：US20140086885A1

公开(公告)日：2014-03-27

申请号：US13837027

申请日：2013-03-15

申请人： C/O SANGAMO BIOSCIENCES, INC.

发明人： Fyodor Urnov ,  Michael C. Holmes ,  Jeffrey C. Miller ,  Carl O. Pabo

IPC分类号： C12N15/85

CPC分类号： A61K35/12 ,  C07K14/43595 ,  C07K14/4717 ,  C07K14/715 ,  C07K2319/00 ,  C07K2319/09 ,  C07K2319/81 ,  C12N9/14 ,  C12N9/22 ,  C12N15/62 ,  C12N15/85 ,  C12N2800/80

摘要： Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins.

公开(公告)号：US20130198878A1

公开(公告)日：2013-08-01

申请号：US13828218

申请日：2013-03-14

申请人： C/O SANGAMO BIOSCIENCES, INC.

发明人： Yannick Doyon ,  Jeffrey C. Miller ,  Fyodor Urnov

IPC分类号： A01K67/027 ,  C12N15/82 ,  C12N15/85

CPC分类号： A01K67/0276 ,  C12N15/8213 ,  C12N15/8509

摘要： Disclosed herein are homozygously modified organisms and methods of making and using these organisms.

摘要翻译： 本文公开了纯合修饰的生物体和制备和使用这些生物体的方法。