公开(公告)号：US20100152258A1

公开(公告)日：2010-06-17

申请号：US12312225

申请日：2007-12-11

申请人： lyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali

发明人： lyassu K. Sebhat ,  Michael Man-chu Lo ,  Ravi P. Nargund ,  Amjad Ali

IPC分类号： A61K31/4178 ,  C07D403/10 ,  A61P9/12

CPC分类号： C07D209/10 ,  C07C65/21 ,  C07C215/82 ,  C07C217/92 ,  C07D209/12 ,  C07D307/80 ,  C07D319/18 ,  C07D401/06 ,  C07D403/10 ,  C07D405/04 ,  C07D409/04

摘要： A compound having the structure (Formula I), wherein Y is —Y1, —Y2, —Y3, —Y4, —Y5; Y1 is C(O) or C(R1R2); Y2 is O, C(O), P(O)(OH) or CH2, provided that when Y1 is C(O), Y2 is not C(O); R1 is selected from the group consisting of hydrogen and C1-4 alkyl; R2 is selected from the pup consisting of hydrogen, C1-4 alkyl, and —OC(O)C1-4 alkyl; Y3 is O, C(O) or CH2, provided that when Y2 is C(O), then Y3 is not C(O), and further provided that when Y2 is O, then Y3 is not O; Y4 is O or CH2 or is absent, provided that when Y3 is O, then Y4 is not O; Y5 is —(CH2)1-2—(X)0-1—(CH2)0-1— or is absent; X is —O— or —CR3R4—; and R3 and R4 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; or a pharmaceutically acceptable salt thereof, which is useful for treating hypertension.

摘要翻译： 具有结构（式I）的化合物，其中Y为-Y1，-Y2，-Y3，-Y4，-Y5; Y1是C（O）或C（R1R2）; Y2是O，C（O），P（O）（OH）或CH2，条件是当Y1是C（O）时，Y2不是C（O）; R 1选自氢和C 1-4烷基; R2选自由氢，C 1-4烷基和-OC（O）C 1-4烷基组成的小鼠; Y3为O，C（O）或CH2，条件是当Y2为C（O）时，Y3不为C（O），进一步规定，当Y2为O时，Y3不为O; Y4为O或CH2或不存在，条件是当Y 3为O时，Y 4不为O; Y 5是 - （CH 2）1-2 - （X）0-1 - （CH 2）0-1-或不存在; X是-O-或-CR 3 R 4 - ; 并且R 3和R 4独立地选自氢和C 1 -C 4烷基; 或其药学上可接受的盐，其可用于治疗高血压。