公开(公告)号：US11081208B2

公开(公告)日：2021-08-03

申请号：US15242256

申请日：2016-08-19

Applicant: 10X GENOMICS, INC.

Inventor： David Jaffe ,  Patrick Marks ,  Michael Schnall-Levin ,  Neil Weisenfeld

IPC: G01N33/48 ,  G01N33/50 ,  G16B30/00

Abstract: Described are computer-implemented methods, systems, and media for de novo phased diploid assembly of nucleic acid sequence data generated from a nucleic acid sample of an individual utilizing nucleic acid tags to preserve long-range sequence context for the individual such that a subset of short-read sequence data derived from a common starting sequence shares a common tag. The phased diploid assembly is achieved without alignment to a reference sequence derived from organisms other than the individual. The methods, systems, and media described are computer-resource efficient, allowing scale-up.

公开(公告)号：US20170235876A1

公开(公告)日：2017-08-17

申请号：US15242256

申请日：2016-08-19

Applicant: 10X GENOMICS, INC.

Inventor： David Jaffe ,  Patrick Marks ,  Michael Schnall-Levin ,  Neil Weisenfeld

IPC: G06F19/22

CPC classification number: G16B30/00

Abstract: Described are computer-implemented methods, systems, and media for de novo phased diploid assembly of nucleic acid sequence data generated from a nucleic acid sample of an individual utilizing nucleic acid tags to preserve long-range sequence context for the individual such that a subset of short-read sequence data derived from a common starting sequence shares a common tag. The phased diploid assembly is achieved without alignment to a reference sequence derived from organisms other than the individual. The methods, systems, and media described are computer-resource efficient, allowing scale-up.