公开(公告)号：US20220076784A1

公开(公告)日：2022-03-10

申请号：US17465725

申请日：2021-09-02

Applicant: 10x Genomics, Inc.

Inventor： Li Wang ,  Yiming Kang

IPC: G16B20/40

Abstract: Methods and systems for generating linkage correlations and linkage significances between a first genomic feature and a second genomic feature identified for each of a plurality of cells may be provided. For example, the method may comprise receiving a data matrix comprising a first genomic feature and a second genomic feature identified for each of a plurality of cells; smoothing the data matrix to generate a smoothed matrix; generating linkage correlations between the first genomic feature and second genomic feature identified for each of the plurality of cells in the data matrix; generating linkage significances using multiplication of a plurality of linkage matrixes; and outputting the linkage correlations and linkage significances for each of the plurality of cells in the data matrix.