公开(公告)号：US10968156B2

公开(公告)日：2021-04-06

申请号：US16766887

申请日：2018-12-12

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Rudolf J. Dams ,  Rudy W. Van Campenhout ,  Matthias Conradi ,  Marine Movsisyan ,  Christian Stevens

IPC: C07C45/63

Abstract: The present disclosure relates to a process for the manufacturing of a 3-5 halopropionylhalide, wherein the process comprises the steps of: a) providing a flow reactor comprising a reaction chamber; b) providing reactants comprising: i. acrylic acid; ii. a reaction co-agent selected from the group consisting of N,N-0 disubstituted amides; and iii. a halogenating agent; and c) incorporating the reactants into the reaction chamber of the flow reactor, thereby forming a reaction product stream comprising a 3-halopropionyl-halide; wherein the molar ratio of acrylic acid to the halogenating agent is 1 to at least 5 0.8; wherein the temperature of the reaction chamber of the flow reactor is greater than 60° C.; and wherein the residence time of the reaction product stream comprising the 3-halopropionylhalide in the reaction chamber of the flow reactor is greater than 10 minutes.

公开(公告)号：US20200331837A1

公开(公告)日：2020-10-22

申请号：US16766871

申请日：2018-12-12

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Rudolf J. Dams ,  Rudy W. Van Campenhout ,  Matthias Conradi ,  Marine Movsisyan ,  Christian Stevens

IPC: C07C51/60 ,  B01J19/24

Abstract: The present disclosure relates to a process for the manufacturing of an acid halide, wherein the process comprises the steps of: a) providing a flow reactor comprising a reaction chamber; b) providing reactants comprising: i. a carboxylic acid; ii. a reaction co-agent selected from the group consisting of N,N-disubstituted amides; and iii. a phosphoryl halide; c) incorporating the reactants into the reaction chamber of the flow reactor, wherein the molar ratio of the carboxylic acid to the phosphoryl halide is 1 to at least 0.8, and the molar ratio of the carboxylic acid to the co-agent is 1 to at least 0.5; and d) producing a reaction product stream comprising the acid halide. In another aspect, the present disclosure is directed to the use of a phosphoryl halide for the manufacturing of an acid halide in a flow reactor.