公开(公告)号：US20030199538A1

公开(公告)日：2003-10-23

申请号：US10306019

申请日：2002-11-27

Applicant: 3M Innovative Properties Company

Inventor： Raymond D. Skwierczynski ,  Terri F. Busch ,  Amy L. Gust-Heiting ,  Mary Fretland ,  Matthew T. Scholz

IPC: A61K031/4745 ,  A61K031/20

CPC classification number: A61K31/437 ,  A61K9/0014 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/4375 ,  A61K31/4745 ,  A61K47/10 ,  A61K47/14 ,  A61K47/32 ,  A61K47/36 ,  A61K47/44

Abstract: Pharmaceutical formulations comprising an immune response modifier (IRM) chosen from imidazoquinoline amines, imidazotetrahydroquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, thiazolo-quinolineamines, oxazolo-quinolinamines, thiazolo-pyridinamines, oxazolo-pyridinamines, imidazonaphthyridine amines, tetrahydroimidazonaphthyridine amines, and thiazolonaphthyridine amines; a fatty acid; and a hydrophobic, aprotic component miscible with the fatty acid are useful for the treatment of dermal associated conditions. Novel topical formulations are provided. In one embodiment, the topical formulations are advantageous for treatment of actinic keratosis, postsurgical scars, basal cell carcinoma, atopic dermatitis, and warts.

Abstract translation: 包含选自咪唑并喹啉胺，咪唑四氢喹啉胺，咪唑并吡啶胺，6,7-稠合的环烷基咪唑并吡啶胺，1,2-桥连的咪唑并喹啉胺，噻唑并喹啉胺，恶唑并喹啉胺，噻唑并 - 吡啶胺，恶唑啉 吡啶胺，咪唑并吡啶胺，四氢咪唑并吡啶胺和噻唑烷吡啶胺; 脂肪酸 并且与脂肪酸可混溶的疏水性非质子组分可用于治疗真皮相关病症。 提供新的局部制剂。 在一个实施方案中，局部制剂有利于治疗光化性角化病，术后瘢痕，基底细胞癌，特应性皮炎和疣。