公开(公告)号：US20210230116A1

公开(公告)日：2021-07-29

申请号：US17090375

申请日：2020-11-05

申请人： 89BIO LTD

发明人： Nadine C. Becknell ,  Reddeppa Reddy Dandu ,  Bruce D. Dorsey ,  Dimitar B. Gotchev ,  Robert L. Hudkins ,  Linda Weinberg ,  Craig A. Zificsak ,  Allison L. Zulli

IPC分类号： C07D211/44 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04 ,  C07D471/08 ,  C07D491/048 ,  C07D495/02 ,  C07D211/54 ,  C07D211/58 ,  C07D401/04 ,  C07D409/12 ,  C07D495/04

摘要： Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

公开(公告)号：US20240166625A1

公开(公告)日：2024-05-23

申请号：US18526380

申请日：2023-12-01

申请人： 89BIO LTD

发明人： Nadine C. Becknell ,  Reddeppa Reddy Dandu ,  Bruce D. Dorsey ,  Dimitar B. Gotchev ,  Robert L. Hudkins ,  Linda Weinberg ,  Craig A. Zificsak

IPC分类号： C07D401/10 ,  C07D405/10 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D401/10 ,  C07D405/10 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

摘要： Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds. Also described herein are methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

公开(公告)号：US11878966B2

公开(公告)日：2024-01-23

申请号：US17175751

申请日：2021-02-15

申请人： 89BIO LTD

发明人： Nadine C. Becknell ,  Reddeppa Reddy Dandu ,  Bruce D. Dorsey ,  Dimitar B. Gotchev ,  Robert L. Hudkins ,  Linda Weinberg ,  Craig A. Zificsak

IPC分类号： C07D401/10 ,  C07D405/10 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D401/10 ,  C07D405/10 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

摘要： Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds. Also described herein are methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

公开(公告)号：US20220081411A1

公开(公告)日：2022-03-17

申请号：US17175751

申请日：2021-02-15

申请人： 89BIO LTD

发明人： Nadine C. Becknell ,  Reddeppa Reddy Dandu ,  Bruce D. Dorsey ,  Dimitar B. Gotchev ,  Robert L. Hudkins ,  Linda Weinberg ,  Craig A. Zificsak

IPC分类号： C07D401/10 ,  C07D405/10 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

摘要： Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds. Also described herein are methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

公开(公告)号：US10919875B2

公开(公告)日：2021-02-16

申请号：US15735811

申请日：2016-06-17

申请人： 89BIO LTD

发明人： Nadine C. Becknell ,  Reddeppa Reddy Dandu ,  Bruce D. Dorsey ,  Dimitar B. Gotchev ,  Robert L. Hudkins ,  Linda Weinberg ,  Craig A. Zificsak

IPC分类号： C07D471/04 ,  C07D413/14 ,  C07D401/10 ,  C07D405/10 ,  C07D405/14

摘要： Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds. Also described herein are methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

公开(公告)号：US20190152913A1

公开(公告)日：2019-05-23

申请号：US16257591

申请日：2019-01-25

申请人： 89BIO LTD

发明人： Nadine C. Becknell ,  Reddeppa Reddy Dandu ,  Bruce D. Dorsey ,  Dimitar B. Gotchev ,  Robert L. Hudkins ,  Linda Weinberg ,  Craig A. Zificsak ,  Allison L. Zulli

IPC分类号： C07D211/44 ,  C07D495/04 ,  C07D401/14 ,  C07D211/54 ,  C07D211/58 ,  C07D401/04 ,  C07D495/02 ,  C07D491/048 ,  C07D471/08 ,  C07D471/04 ,  C07D471/02 ,  C07D417/14 ,  C07D417/12 ,  C07D409/14 ,  C07D405/12 ,  C07D405/06 ,  C07D401/12 ,  C07D413/14 ,  C07D405/14 ,  C07D409/12

摘要： Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

公开(公告)号：US12098130B2

公开(公告)日：2024-09-24

申请号：US18327986

申请日：2023-06-02

申请人： 89BIO LTD

发明人： Nadine C. Becknell ,  Reddeppa Reddy Dandu ,  Bruce D. Dorsey ,  Dimitar B. Gotchev ,  Robert L. Hudkins ,  Linda Weinberg ,  Craig A. Zificsak ,  Allison Zulli

IPC分类号： C07D211/44 ,  C07D211/54 ,  C07D211/58 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04 ,  C07D471/08 ,  C07D491/048 ,  C07D495/02 ,  C07D495/04

CPC分类号： C07D211/44 ,  C07D211/54 ,  C07D211/58 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04 ,  C07D471/08 ,  C07D491/048 ,  C07D495/02 ,  C07D495/04

摘要： Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

公开(公告)号：US20230391723A1

公开(公告)日：2023-12-07

申请号：US18327986

申请日：2023-06-02

申请人： 89BIO LTD

发明人： Nadine C. Becknell ,  Reddeppa Reddy Dandu ,  Bruce D. Dorsey ,  Dimitar B. Gotchev ,  Robert L. Hudkins ,  Linda Weinberg ,  Craig A. Zificsak ,  Allison Zulli

IPC分类号： C07D211/44 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04 ,  C07D471/08 ,  C07D491/048 ,  C07D495/02 ,  C07D211/54 ,  C07D211/58 ,  C07D401/04 ,  C07D409/12 ,  C07D495/04

CPC分类号： C07D211/44 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04 ,  C07D471/08 ,  C07D491/048 ,  C07D495/02 ,  C07D211/54 ,  C07D211/58 ,  C07D401/04 ,  C07D409/12 ,  C07D495/04

摘要： Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

公开(公告)号：US11702388B2

公开(公告)日：2023-07-18

申请号：US17090375

申请日：2020-11-05

申请人： 89BIO LTD

发明人： Nadine C. Becknell ,  Reddeppa Reddy Dandu ,  Bruce D. Dorsey ,  Dimitar B. Gotchev ,  Robert L. Hudkins ,  Linda Weinberg ,  Craig A. Zificsak ,  Allison L. Zulli

IPC分类号： C07D211/44 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04 ,  C07D471/08 ,  C07D491/048 ,  C07D495/02 ,  C07D211/54 ,  C07D211/58 ,  C07D401/04 ,  C07D409/12 ,  C07D495/04

CPC分类号： C07D211/44 ,  C07D211/54 ,  C07D211/58 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/02 ,  C07D471/04 ,  C07D471/08 ,  C07D491/048 ,  C07D495/02 ,  C07D495/04

摘要： Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.

公开(公告)号：US10221135B2

公开(公告)日：2019-03-05

申请号：US15903150

申请日：2018-02-23

申请人： 89BIO LTD

发明人： Nadine C. Becknell ,  Reddeppa Reddy Dandu ,  Bruce D. Dorsey ,  Dimitar B. Gotchev ,  Robert L. Hudkins ,  Linda Weinberg ,  Craig A. Zificsak ,  Allison L. Zulli

IPC分类号： C07D211/44 ,  C07D211/54 ,  C07D409/12 ,  C07D401/04 ,  C07D495/04 ,  C07D211/58 ,  C07D405/06 ,  C07D471/04 ,  C07D413/14 ,  C07D495/02 ,  C07D401/14 ,  C07D417/14 ,  C07D471/02 ,  C07D491/048 ,  C07D401/12 ,  C07D405/14 ,  C07D471/08 ,  C07D405/12 ,  C07D409/14 ,  C07D417/12

摘要： Described herein are 1,4-substituted piperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described 1,4-substituted piperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described 1,4-substituted piperidine compounds and synthetic intermediates useful in those syntheses.