公开(公告)号：US20230293561A1

公开(公告)日：2023-09-21

申请号：US18006802

申请日：2021-07-26

申请人： ABBOTT LABORATORIES

发明人： Manuel MANZANO ,  Enrique HERNANDEZ ,  José María LÓPEZ PEDROSA ,  Ricardo RUEDA CABRERA ,  Rachael BUCK

IPC分类号： A61K31/702 ,  A61K45/06 ,  A61P3/06 ,  A61K9/00 ,  A61P1/16

CPC分类号： A61K31/702 ,  A61K45/06 ,  A61P3/06 ,  A61K9/0053 ,  A61P1/16

摘要： A method of reducing or delaying the onset of fatty liver disease in a subject comprises enterally administering at least one human milk oligosaccharide (HMO) to a subject in need thereof in an amount effective to reduce hepatic lipid accumulation. In a specific embodiment, the at least one HMO is administered in an amount effective to reduce de novo lipogenesis in the subject. The at least one HMO can be administered to the subject directly or in a nutritional composition.