公开(公告)号：US20230051266A1

公开(公告)日：2023-02-16

申请号：US17783344

申请日：2020-12-10

Applicant: ABL BIO INC.

Inventor： Kyung Jin PARK ,  Yang Soon LEE ,  Sae Yi LIM ,  Hye Jin CHUNG ,  Kyeong Su PARK ,  Yong Gyu SON ,  Seong Gyu SEON ,  Won Jun SON ,  Eun Jung KIM ,  Jae Hyun EOM ,  Ui Jung JUNG ,  Min Ji PARK ,  Jung Hyeon HONG

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/46

Abstract: An anti-B-cell maturation antigen (BCMA)/anti-4-1BB bispecific antibody or an antigen-binding fragment thereof, and use thereof, are provided. The bispecific antibody or an antigen-binding fragment thereof may have high binding affinity to both of a BCMA protein and a 4-1BB protein and may be effectively used to prevent or treat a disease related to BCMA, 4-1BB, or both thereof (e.g., cancer).