公开(公告)号：US20240066113A1

公开(公告)日：2024-02-29

申请号：US18029758

申请日：2022-04-12

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey WONG ,  Chung-Yi WU ,  Che MA ,  Chen-Yu FAN

IPC: A61K39/215 ,  A61K9/127 ,  A61P31/14 ,  C07K14/165

CPC classification number: A61K39/215 ,  A61K9/127 ,  A61P31/14 ,  C07K14/165 ,  A61K2039/545

Abstract: The present invention relates to the mRNA vaccine of coronavirus spike protein with deletion of glycosites in the receptor binding domain (RBD), the subunit 1 (S1) domain, or the subunit 2 (S2) domain, or a combination thereof. The vaccine elicits broadly protective immune responses coronavirus and variants thereof.