公开(公告)号：US11254722B2

公开(公告)日：2022-02-22

申请号：US16483371

申请日：2018-02-06

Applicant: ACADEMIA SINICA

Inventor： Elizabeth Wang

IPC: A61K38/00 ,  C07K14/47 ,  A61P35/00 ,  C07K14/52 ,  A61K33/243 ,  A61K31/351 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/517 ,  A61K31/5377

Abstract: Disclosed herein are recombinant proteins including an IGFBP3 or a biologically active fragment thereof and an IgG Fc portion linked to the C-terminus of the IGFBP3 variant. The recombinant proteins including at least one additional domain of other growth factors are also disclosed. Methods for treating tumors, in particular, tumors resistant to the targeted therapy, using the above-mentioned recombinant proteins are also provided.