公开(公告)号：US20160166661A1

公开(公告)日：2016-06-16

申请号：US14906663

申请日：2014-07-26

Applicant: ACADEMIA SINICA

Inventor： Chi-Huey WONG ,  Chung-Yi WU ,  Hsien-Yeh HSU ,  Shih-Fen LIAO ,  Chi-Hui LIANG

IPC: A61K39/00

CPC classification number: A61K39/0002 ,  A61K36/074 ,  A61K39/0011 ,  A61K2039/55572 ,  A61K2039/575

Abstract: Immunogenic compositions, cancer vaccines and methods for treating cancer comprising FMS, the fucose-enriched polysaccharide fraction from Reishi F3, are provided. Compositions comprise fucose-enriched Reishi polysaccharide fraction (FMS) MW=˜35 kDa, wherein the FMS is isolated by size-exclusion chromatography from Reishi F3, and the FMS comprises polysaccharides having primarily a backbone selected from 1,4-mannan and 1,6-α-galactan, wherein the backbone is linked to a terminal fucose-containing side-chain Immunogenic compositions comprising glycolipid adjuvants are provided. Antibodies generated by immunogenic compositions disclosed herein bind cancer cells comprising antigens Globo H, Globo H, Gb3, Gb4, Gb5 (SSEA-3) and SSEA-4 on the cell surface.

Abstract translation: 提供免疫原性组合物，癌症疫苗和治疗癌症的方法，其包括FMS，来自Reishi F3的岩藻糖富集的多糖部分。 组合物包含岩藻糖富集的赖斯多糖级分（FMS）MW =〜35kDa，其中通过来自Reishi F3的尺寸排阻色谱法分离FMS，并且FMS包含主要选自1,4-甘露聚糖和1， 6-α-半乳聚糖，其中所述主链与包含末端岩藻糖的侧链连接，提供包含糖脂佐剂的免疫原性组合物。 由本文公开的免疫原性组合物产生的抗体结合细胞表面上包含抗原Globo H，Globo H，Gb 3，Gb 4，Gb 5（SSEA-3）和SSEA-4的癌细胞。