公开(公告)号：US20250129146A1

公开(公告)日：2025-04-24

申请号：US18572564

申请日：2022-06-24

Applicant: ACADEMIA SINICA

Inventor： Han-Chung WU ,  Sushree Shankar PANDA

IPC: C07K16/22 ,  A61K31/497 ,  A61K39/00 ,  A61P35/00

Abstract: The present invention relates to combined therapy of cancer using an epithelial cell adhesion molecule (EpCAM) inhibitor and a Wnt signaling inhibitor. Specifically, the EpCAM inhibitor is an antibody which is directed to an extracellular domain (EpEX) of EpCAM. The combined therapy is effective in inducing apoptosis of cancer cells, inhibiting cancer sternness properties, tumor progression and/or metastasis, and/or prolonging survival of a cancer patient.