公开(公告)号：US20150126583A1

公开(公告)日：2015-05-07

申请号：US14534466

申请日：2014-11-06

Applicant: ACADEMIA SINICA

Inventor： FU-TONG LIU ,  WEI-CHEN HSIEH ,  RI-YAO YANG

IPC: C12N15/113 ,  C12N15/115

CPC classification number: C12N15/113 ,  C12N2310/14

Abstract: Methods for the treatment of a disorder characterized by excessive proliferation and/or lipid content of sebocytes are disclosed. In one embodiment of the invention, the method comprises administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a small molecule inhibitor targeted to galectin-12 or a nucleic acid-based inhibitor targeted to galectin-12 and a pharmaceutically acceptable carrier, wherein said inhibitor is a non-naturally occurring molecule and administration of said inhibitor produces a decrease in the proliferation and/or lipid content of the sebocytes. Methods for decreasing sebaceous gland size, inhibiting sebocyte proliferation, and/or inhibiting sebocyte lipid content are also disclosed.

Abstract translation: 公开了治疗以皮脂细胞过度增殖和/或脂质含量为特征的病症的方法。 在本发明的一个实施方案中，所述方法包括向有需要的受试者施用治疗有效量的药物组合物，其包含靶向半乳凝素-12的小分子抑制剂或靶向半乳凝素-12的核酸抑制剂和药学上 其中所述抑制剂是非天然存在的分子，并且所述抑制剂的施用会导致皮脂细胞的增殖和/或脂质含量的降低。 还公开了降低皮脂腺体积大小，抑制血细胞增殖和/或抑制血细胞脂质含量的方法。